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Neurobiology of Aging
Volume 29, Issue 1
, Pages 39-50
, January 2008
Region specific neuron loss in the aged canine hippocampus is reduced by enrichment
References
- . Hippocampal involvement in spatial and working memory: a structural MRI analysis of patients with unilateral mesial temporal lobe sclerosis. Brain Cogn. 1999;41:39–65
- . Atlas of the Canine Brain. (Translation of Atlas mozga sobaki: Moscow, 1959). Ann Arbor: University of Michigan; 1964;
- . Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. U.S.A. 1993;90(17):7915–7922
- . DNA damage and apoptosis in the aged canine brain: relationship to Abeta deposition in the absence of neuritic pathology. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2000;24(5):787–799
- AAFCO, American Association of Feed Control Officials. Commercial Feed Annual Report, 1999.
- . Estradiol prevents kainic acid-induced neuronal loss in the rat dentate gyrus. Neuroreport. 1998;9(13):3075–3079
- . Growth hormone prevents neuronal loss in the aged rat hippocampus. Neurobiol. Aging. 2005;26(5):697–703
- . Paucity of morphological changes in the brains of ageing beagle dogs: further evidence that Alzheimer lesions are unique for primate central nervous system. Neurobiol. Aging. 1983;4:127–131
- . Reduced hippocampal neurogenesis and number of hilar neurons in streptozotocin-induced diabetic mice: reversion by antidepressant treatment. Eur. J. Neurosci. 2006;23:1539–1546
- . Absence of temporal lobe epilepsy pathology in dogs with medically intractable epilepsy. J. Vet. Intern. Med. 2002;16(1):95–99
- . Hilar neuropeptide Y interneuron loss in the aged rat hippocampal formation. Exp. Neurol. 2003;183:147–158
- . Alpha-tocopherol, an exogenous factor of adult hippocampal neurogenesis regulation. J. Neurosci. Res. 2003;73(4):447–455
- . Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility. Behav. Neurosci. 2002;116(3):443–454
- . Neural precursor proliferation and newborn cell survival in the adult rat dentate gyrus are affected by vitamin E deficiency. Neurosci. Res. 2002;44(4):369–377
- . Neurogenesis in the adult rat dentate gyrus is enhanced by Vitamin E deficiency. J. Comp. Neurol. 1999;411(3):495–502
- . A focus on the synapse for neuroprotection in Alzheimer disease and other dementias. Neurology. 2004;63(7):1155–1162
- . Beta Amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiol. Learn. Mem. 1996;66:11–23
- . Tocopherols enhance neurogenesis in dentate gyrus of adult rats. Int. J. Vitam Nutr. Res. 2002;72(3):170–176
- . Chronic stress decreases the number of parvalbumin-immunoreactive interneurons in the hippocampus: prevention by treatment with a substance P receptor (NK1) antagonist. Neuropsychopharm. 2005;30:67–79
- . Dysmorphic neurons in patients with temporal lobe epilepsy. Brain Res. 2006;1072:200–207
- . The aging hippocampus: navigating between rat and human experiments. Rev. Neurosci. 2005;16(2):87–121
- . Environmental enrichment in adulthood eliminates neuronal death in experimental Parkinsonism. Brain Res. Mol. Brain Res. 2005;134(1):170–179
- . Vitamin E affects cell death in adult rat dentate gyrus. J. Neurocytol. 2003;32(9):1155–1164
- . Integrative Development of Brain and Behavior in the Dog. Chicago: The University of Chicago Press; 1971;
- . Preserved number of entorhinal cortex layer II neurons in aged macaque monkeys. Neurobiol. Aging. 1997;18(5):549–553
- . Neuronal density, size and shape in the human anterior cingulate cortex: a comparison of Nissl and NeuN staining. Brain Res. Bull. 2004;63(2):155–160
- . Right hippocampal contribution to visual memory: a presurgical and postsurgical study in patients with temporal lobe epilepsy. J. Neurol. Neurosurg. Psychiatry. 1998;65:665–669
- . Severe amnesia in epilepsy: causes, anatomopsychological considerations and treatment. Epilepsy Behav. 2001;2:224–246
- . The efficiency of systematic sampling in stereology-reconsidered. J. Microsc. 1999;193(Pt 3):199–211
- . Variation in hippocampal neuron number with age and brain volume. Cereb. Cortex. 1998;8(8):710–718
- . Role of free radicals in aging and disease. Ann. N Y Acad. Sci. 1992;673:126–141
- . Analysis of cell death in the trochlear nucleus of the chick embryo: calibration of the optical disector counting method reveals systematic bias. J. Comp. Neurol. 1999;409:169–186
- . Open field activity and human interaction as a function of age and breed in dogs. Physiol. Behav. 1997;62(5):963–971
- . Visual-discrimination learning ability and beta-amyloid accumulation in the dog. Neurobiol. Aging. 1998;19(5):415–425
- . Oxidative damage increases with age in a canine model of human brain aging. J. Neurochem. 2002;82(2):375–381
- . Spatial learning and memory as a function of age in the dog. Behav. Neurosci. 1995;109(5):851–858
- . Quantitative investigations on the human entorhinal area: left-right asymmetry and age-related changes. Anat. Embryol. (Berlin). 1994;190(2):181–194
- . Neuropsychological characteristics of the syndrome of mesial temporal lobe epilepsy. Arch. Neurol. 1997;54:369–376
- . Distribution of neurofilament protein and calcium-binding proteins parvalbumin, calbindin, and calretinin in the canine hippocampus. J. Chem. Neuroanat. 1996;11:1–12
- . More hippocampal neurons in adult mice living in an enriched environment. Nature. 1997;386(6624):493–495
- . Preservation of hippocampal neuron numbers in aged rhesus monkeys. Neurobiol Aging. 2003;24(1):157–165
- . Apoptosis in the aged dog brain. Acta Neuropathol. (Berlin). 1996;92(3):242–248
- . Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment. Ann. Neurol. 2001;49(2):202–213
- . Effect of prenatal protein malnutrition on numbers of neurons in the principal cell layers of the adult rat hippocampal formation. Hippocampus. 2005;15:393–403
- . Conservation of neuronal number and size in the entorhinal cortex of behaviorally characterized aged rats. J. Comp. Neurol. 2001;438(4):445–456
- . Conservation of neuron number and size in entorhinal cortex layers II, III, and V/VI of aged primates. J. Comp. Neurol. 2000;422(3):396–401
- . Landmark discrimination learning in the dog. Learn. Mem. 1999;6(1):54–61
- . Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy. Neurosci. Biobehav. Rev. 2002;26(6):679–695
- . Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a 2-year longitudinal study. Neurobiol. Aging. 2005;26(1):77–90
- . Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs. Exp Gerontol. 2004;39(5):753–765
- . Dietary enrichment counteracts age-associated cognitive dysfunction in canines. Neurobiol. Aging. 2002;23(5):737–745
- . Gabaergic inhibition of granule cells and hilar neuronal synchrony following ischemia-induced hilar neuron loss. Neuroscience. 1995;69(1):139–150
- . Amyloid deposits and loss of neurons in the claustrum of the aged dog. Neuroreport. 1994;5:1825–1828
- . Light and electron microscopic immunohistochemical detection of bromodeoxyuridine-labeled cells in the brain: different fixation and processing protocols. J. Histochem. Cytochem. 2005;53(7):821–832
- . Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways. Hippocampus. 2006;16(3):250–260
- . Immunohistochemical investigation of the brain of aged dogs. I. Detection of neurofibrillary tangles and of 4-hydroxynonenal protein, an oxidative damage product, in senile plaques. Amyloid. 2001;8(1):11–21
- . Abnormalities of the hippocampus are similar in deoxycorticosterone acetate-salt hypertensive rats and spontaneously hypertensive rats. J. Neuroendocrin. 2006;18:466–474
- Pop, V., Head, E., Muggenburg, B.A., Milgram, N.W., Cotman, C.W., 2005. Secretase activity (α,β,γ) as a function of age, antioxidant dietm and/or behavioral enrichment in canine parietal cortex. Program No. 662.8. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience.
- Pop, V., Head, E., Nistor, M., Milgram, N.W., Muggenburg, B.A., Cotman, C.W., 2003. Reduced a αβ deposition with long-term antioxidant diet treatment in aged canines. Program No. 525.4. 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience.
- . Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease. Arch. Neurol. 2001;58(9):1395–1402
- . Gamma-aminobutyric acidergic interneuron vulnerability to aging in canine prefrontal cortex. J. Neurosci. Res. 2004;77(6):913–920
- . Preserved neuron number in the hippocampus of aged rats with spatial learning deficits. Proc. Natl. Acad. U.S.A. 1996;93(18):9926–9930
- . Memory impaired aged rats: no loss of principal hippocampal and subicular neurons. Neurobiol. Aging. 1996;17(1):143–147
- . Histochemical accumulation of oxidative damage products is associated with Alzheimer-like pathology in the canine. Amyloid. 2004;11(2):90–100
- . Hyperbaric oxygen reduces neuronal death and improves neurological outcome after canine cardiac arrest. Stroke. 2003;34:1311–1316
- . Age-specific onset of beta-amyloid in beagle brains. Neurobiol. Aging. 1996;17(2):269–273
- . Vulnerability of the dentate gyrus to aging and intracerebroventricular administration of kainic acid. Exp. Neurol. 1999;158(2):491–503
- . Oxidative damage and mitochondrial decay in aging. Proc. Natl. Acad. Sci. U.S.A. 1994;91(23):10771–10778
- . Hemispheric asymmetry, modular variability and age-related changes in the human entorhinal cortex. Neuroscience. 2005;130:911–925
- . Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer's disease. J. Comp. Neurol. 1997;379(4):482–494
- Siwak, C.T., Head, E., Muggenburg, B.A., Milgram, N.W., Cotman, C.W., 2006. Neurogenesis decreases with age in the dog and correlates with cognitive function. Program No. 674.8. 2006 Neuroscience Meeting Planner. Atlanta, GA, Society for Neuroscience, 2006. (Online).
- . Age-dependent decline in locomotor activity in dogs is environment specific. Physiol. Behav. 2002;75(1–2):65–70
- . Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2005;29(3):461–469
- . Effect of age and level of cognitive function on spontaneous and exploratory behaviors in the beagle dog. Learn. Mem. 2001;8(6):317–325
- . Locomotor activity rhythms in dogs vary with age and cognitive status. Behav. Neurosci. 2003;117(4):813–824
- . The role of free radicals in canine counterpart of senile dementia of the Alzheimer type. Exp. Gerontol. 2003;38(6):711–719
- . Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging. Neurobiol. Aging. 1998;19(5):479–485
- . A longitudinal study of brain morphometrics using serial magnetic resonance imaging analysis in a canine model of aging. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2005;29(3):389–397
- . Effects of scopolamine challenge on regional cerebral blood volume. A pharmacological model to validate the use of contrast enhanced magnetic resonance imaging to assess cerebral blood volume in a canine model of aging. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2005;29(3):399–406
- . Application of an automated voxel-based morphometry technique to assess regional gray and white matter brain atrophy in a canine model of aging. Neuroimage. 2006;29(1):234–244
- . The canine model of human brain aging: cognition, behavior, and neuropathology. In: Conn PM editors. Handbook of Models for Human Aging. Amsterdam: Elsevier; 2006;p. 415–434
- . Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learn. Mem. 2003;10(1):64–73
- . Effects of age on measures of complex working memory span in the beagle dog (Canis familiaris) using two versions of a spatial list learning paradigm. Learn. Mem. 2003;10(2):148–160
- . Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. J. Neurosci. 2004;24(38):8205–8213
- . Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks. Behav. Brain Res. 2004;153(1):199–210
- . Environmental enrichment and isolation rearing in the rat: effects on locomotor behavior and startle response plasticity. Biol. Psychiatry. 2000;47(10):864–873
- . Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, metabolic dysfunction, and neuronal death. J. Cereb. Blood Flow Metab. 2006;26:821–835
- . Cognitive impact of neuronal pathology in the entorhinal cortex and CA1 field in Alzheimer's disease. Neurobiol. Aging. 2006;27(2):270–277
- . Regionally specific loss of neurons in the aging human hippocampus. Neurobiol. Aging. 1993;14(4):287–293
- . Preserved hippocampal cell number in aged monkeys with recognition deficits. Soc. Neurosci. Abstr. 1993;19:559
- . Unbiased stereological estimation of the number of neurons in the human hippocampus. J. Comp. Neurol. 1990;296(1):1–22
- . The CA1 region of the human hippocampus is a hot spot in Alzheimer's disease. Ann. NY Acad. Sci. 2000;908:255–259
- . Total number of neurons in the layers of the human entorhinal cortex. Hippocampus. 1998;8(1):69–82
- . Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat. Rec. 1991;231(4):482–497
- . Senile plaques and cerebral amyloidosis in aged dogs. A histochemical and ultrastructural study. Lab Invest. 1970;23(3):287–296
- . Cytoarchitecture of the canine perirhinal and postrhinal cortex. Acta Neurobiol. Exp. (Wars). 2003;63(3):197–209
- . Cytoarchitectonic organization of the entorhinal cortex of the canine brain. Brain Res. Brain Res. Rev. 2006;52(2):346–367
- . Enduring memory impairment in monkeys after ischemic damage to the hippocampus. J. Neurosci. 1992;12(7):2582–2596
PII: S0197-4580(06)00355-1
doi: 10.1016/j.neurobiolaging.2006.09.018
© 2006 Elsevier Inc. All rights reserved.
« Previous
Next »
Neurobiology of Aging
Volume 29, Issue 1
, Pages 39-50
, January 2008
