Neurobiology of Aging
Volume 29, Issue 1 , Pages 31-38 , January 2008

MRI of hippocampus and entorhinal cortex in mild cognitive impairment: A follow-up study

  • Tero Tapiola

      Affiliations

    • Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
    • Department of Neurology, Kuopio University Hospital, 70211 Kuopio, Finland
    • Corresponding Author InformationCorresponding author at: Department of Neurology, Kuopio University Hospital, P.O. Box 1777, FIN 70211 Kuopio, Finland. Tel.: +358 44 7113135; fax: +358 17 173019.
  • ,
  • Corina Pennanen

      Affiliations

    • Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
    • Department of Neurology, Kuopio University Hospital, 70211 Kuopio, Finland
    • Department of Clinical Radiology, Kuopio University Hospital, 70211 Kuopio, Finland
  • ,
  • Mia Tapiola

      Affiliations

    • Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
  • ,
  • Susanna Tervo

      Affiliations

    • Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
  • ,
  • Miia Kivipelto

      Affiliations

    • Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
  • ,
  • Tuomo Hänninen

      Affiliations

    • Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
    • Department of Neurology, Kuopio University Hospital, 70211 Kuopio, Finland
  • ,
  • Maija Pihlajamäki

      Affiliations

    • Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
    • Department of Neurology, Kuopio University Hospital, 70211 Kuopio, Finland
  • ,
  • Mikko P. Laakso

      Affiliations

    • Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
    • Department of Clinical Radiology, Kuopio University Hospital, 70211 Kuopio, Finland
  • ,
  • Merja Hallikainen

      Affiliations

    • Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
  • ,
  • Anne Hämäläinen

      Affiliations

    • Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
  • ,
  • Matti Vanhanen

      Affiliations

    • Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
  • ,
  • Eeva-Liisa Helkala

      Affiliations

    • Department of Public Health, University of Kuopio, 70211 Kuopio, Finland
  • ,
  • Ritva Vanninen

      Affiliations

    • Department of Clinical Radiology, Kuopio University Hospital, 70211 Kuopio, Finland
  • ,
  • Aulikki Nissinen

      Affiliations

    • National Institute of Public Health, Mannerheimintie 116, 00300 Helsinki, Finland
  • ,
  • Roberta Rossi

      Affiliations

    • LENITEM, IRCCS San Giovanni di Dio-FBF, Brescia, Italy
  • ,
  • Giovanni B. Frisoni

      Affiliations

    • LENITEM, IRCCS San Giovanni di Dio-FBF, Brescia, Italy
  • ,
  • Hilkka Soininen

      Affiliations

    • Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
    • Department of Neurology, Kuopio University Hospital, 70211 Kuopio, Finland

Received 13 April 2006 ,Revised 16 August 2006 ,Accepted 15 September 2006.

References 

  1. Albert MS. Cognitive and neurobiologic markers of early Alzheimer disease. Proc Natl Acad Sci USA. 1996;93(24):13547–13551
  2. American Psychiatric Association . Diagnostic and statistical manual of mental disorders. 4th ed.. Washington, DC: American Psychiatric Association; 1994;
  3. Bigler ED, Lowry CM, Anderson CV, Johnson SC, Terry J, Steed M. Dementia, quantitative neuroimaging, and apolipoprotein E genotype. AJNR Am J Neuroradiol. 2000;21(10):1857–1868
  4. Braak H, Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol (Berl). 1991;82(4):239–259
  5. De Santi S, de Leon MJ, Rusinek H, Convit A, Tarshish CY, Roche A, et al. Hippocampal formation glucose metabolism and volume losses in MCI and AD. Neurobiol Aging. 2001;22(4):529–539
  6. deToledo-Morrell L, Stoub TR, Bulgakova M, Wilson RS, Bennett DA, Leurgans S, et al. MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD. Neurobiol Aging. 2004;25:1197–1203
  7. Dickerson BC, Goncharova I, Sullivan MP, Forchetti C, Wilson RS, Bennett DA, et al. MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease. Neurobiol Aging. 2001;22(5):747–754
  8. Du AT, Schuff N, Amend D, Laakso MP, Hsu YY, Jagust WJ, et al. Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2001;71(4):441–447
  9. Geroldi C, Pihlajamäki M, Laakso MP, DeCarli C, Beltramello A, Bianchetti A, et al. ApoE-epsilon4 is associated with less frontal and more medial temporal lobe atrophy in AD. Neurology. 1999;53(8):1825–1832
  10. Geroldi C, Laakso MP, DeCarli C, Beltramello A, Bianchetti A, Soininen H, et al. Apolipoprotein E genotype and hippocampal asymmetry in Alzheimer's disease. A volumetric MRI study. J Neurol Neurosurg Psychiatry. 2000;68(1):93–96
  11. Huesgen CT, Burger PC, Crain BJ, Johnson GA. In vitro MR microscopy of the hippocampus in Alzheimer's disease. Neurology. 1993;43(1):145–152
  12. Hyman BT, Van Hoesen GW, Damasio AR, Barnes CL. Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science. 1984;225(4667):1168–1170
  13. Hänninen T, Hallikainen M, Murtolahti R, Vanhanen M, Soininen H. Prevalence of mild cognitive impairment: a population-based study in elderly subjects. Acta Neurol Scand. 2002;106(3):148–154
  14. Insausti R, Juottonen K, Soininen H, Insausti AM, Partanen K, Vainio P, et al. MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices. Am J Neuroradiol. 1998;19(4):659–671
  15. Jack CR, Petersen RC, Xu YC, O’Brien PC, Smith GE, Ivnik RJ, et al. Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology. 1999;52(7):1397–1403
  16. Juottonen K, Lehtovirta M, Helisalmi S, Riekkinen PJ, Soininen H. Major decrease in the volume of the entorhinal cortex in patients with Alzheimer's disease carrying the apolipoprotein E ɛ4 allele. J Neurol Neurosurg Psychiatry. 1998;65(3):322–327
  17. Killiany RJ, Gomez-Isla T, Moss M, Kikinis R, Sandor T, Jolesz F, et al. Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease. Ann Neurol. 2000;47(4):430–439
  18. Killiany RJ, Hyman BT, Gomez-Isla T, Moss MB, Kikinis R, Jolesz F, et al. MRI measures of entorhinal cortex vs. hippocampus in preclinical AD. Neurology. 2002;58(8):1188–1196
  19. Kivipelto M, Helkala E-L, Hänninen T, Laakso MP, Hallikainen M, Alhainen K, et al. Midlife vascular risk factors and late-life mild cognitive impairment. A population based study. Neurology. 2001;56(12):1683–1689
  20. Kivipelto M, Helkala EL, Laakso MP, Hanninen T, Hallikainen M, Alhainen K, et al. Apolipoprotein E ɛ4 allele, elevated midlife cholesterol and systolic blood pressure are independent risk factors for late-life Alzheimer's disease. Ann Intern Med. 2002;137(3):149–155
  21. Kordower JH, Chu Y, Stebbins GT, DeKosky ST, Cochran EJ, Bennett D, et al. Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment. Ann Neurol. 2001;49(2):202–213
  22. Korf ES, Wahlund LO, Visser PJ, Scheltens P. Medial temporal lobe atrophy on MRI predicts dementia in patients with mild cognitive impairment. Neurology. 2004;63(1):94–100
  23. Larrieu S, Letenneur L, Orgogozo JM, Fabrigoule C, Amieva H, Le Carret N, et al. Incidence and outcome of mild cognitive impairment in a population-based prospective cohort. Neurology. 2002;59(10):1594–1599
  24. Launer LJ. Epidemiology of white-matter lesions. Int Psychogeriatr. 2003;15(Suppl. 1):99–103
  25. Lehtovirta M, Soininen H, Laakso MP, Partanen K, Helisalmi S, Mannermaa A, et al. SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E epsilon 4 allele. J Neurol Neurosurg Psychiatry. 1996;60(6):644–649
  26. Lehtovirta M, Laakso MP, Frisoni GB, Soininen H. How does the apolipoprotein E genotype modulate the brain in aging and in Alzheimer's disease? A review of neuroimaging studies. Neurobiol Aging. 2000;21(2):293–300
  27. Lopez OL, Jagust WJ, Dulberg C, Becker JT, DeKosky ST, Fitzpatrick A, et al. Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 2. Arch Neurol. 2003;60(10):1394–1399
  28. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34(7):939–944
  29. Pennanen C, Kivipelto M, Tuomainen S, Hartikainen P, Hänninen T, Laakso MP, et al. Hippocampus and entorhinal cortex in mild cognitive impairment and early AD. Neurobiol Aging. 2004;25(3):303–310
  30. Petersen RC, Smith GE, Ivnik RJ, Tangalos EG, Schaid DJ, Thibodeau SN, et al. Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals. JAMA. 1995;273(16):1274–1278
  31. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999;56(3):303–308
  32. Petersen RC, Stevens JC, Ganguli M, Tangalos EG, Cummings JL, DeKosky ST. Practice parameter: early detection of dementia—mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2001;56(9):1133–1142
  33. Reiman EM, Caselli RJ, Yun LS, Chen K, Bandy D, Minoshima S, et al. Preclinical evidence of Alzheimer's disease in persons homozygous for the e4 allele for apolipoprotein E. N Engl J Med. 1996;334(12):752–758
  34. Reiman EM, Caselli RJ, Chen K, Alexander GE, Bandy D, Frost J. Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: a foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease. Proc Natl Acad Sci USA. 2001;98(6):3334–3339
  35. Smith GE, Petersen RC, Parisi JE, Ivnik RJ, Kokmen E, Tangalos EG, et al. Definition, course, and outcome of mild cognitive impairment. Aging Neuropsychol Cogn. 1996;3:141–147
  36. Squire LR, Zola-Morgan S. The medial temporal lobe memory system. Science. 1991;253(5026):1380–1386
  37. Tervo S, Kivipelto M, Hänninen T, Vanhanen M, Hallikainen M, Mannermaa A, et al. Incidence and risk factors for mild cognitive impairment: a population-based three year follow-up study of cognitively healthy elderly subjects. Dement Geriatr Cogn Disord. 2004;17(3):196–203
  38. Tsukamoto K, Watanabe T, Matsushima T, Kinoshita M, Kato H, Hashimoto Y, et al. Determination by PCR-RFLP of apo E genotype in a Japanese population. J Lab Clin Med. 1993;121(4):598–602
  39. Van Hoesen GW, Hyman BT. Hippocampal formation: anatomy and the patterns of pathology in Alzheimer's disease. Prog Brain Res. 1990;83:445–457
  40. Van Hoesen GW, Hyman BT, Damasio AR. Entorhinal cortex pathology in Alzheimer's disease. Hippocampus. 1991;1(1):1–8
  41. Wahlund LO, Barkhof F, Fazekas F, Bronge L, Augustin M, Sjogren M, et al. European Task Force on Age-related White Matter Changes. A new rating scale for age-related white matter changes applicable to MRI and CT. Stroke. 2001;32(6):1318–1322

PII: S0197-4580(06)00345-9

doi: 10.1016/j.neurobiolaging.2006.09.007

Neurobiology of Aging
Volume 29, Issue 1 , Pages 31-38 , January 2008