MRI of hippocampus and entorhinal cortex in mild cognitive impairment: A follow-up study

Tapiola, Tero; Pennanen, Corina; Tapiola, Mia; Tervo, Susanna; Kivipelto, Miia; Hänninen, Tuomo; Pihlajamäki, Maija; Laakso, Mikko P.; Hallikainen, Merja; Hämäläinen, Anne; Vanhanen, Matti; Helkala, Eeva-Liisa; Vanninen, Ritva; Nissinen, Aulikki; Rossi, Roberta; Frisoni, Giovanni B.; Soininen, Hilkka

doi:10.1016/j.neurobiolaging.2006.09.007

« Previous Next »Neurobiology of Aging
Volume 29, Issue 1 , Pages 31-38, January 2008

MRI of hippocampus and entorhinal cortex in mild cognitive impairment: A follow-up study

Tero Tapiola
- Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
- Department of Neurology, Kuopio University Hospital, 70211 Kuopio, Finland
- Corresponding author at: Department of Neurology, Kuopio University Hospital, P.O. Box 1777, FIN 70211 Kuopio, Finland. Tel.: +358 44 7113135; fax: +358 17 173019.
Corina Pennanen
- Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
- Department of Neurology, Kuopio University Hospital, 70211 Kuopio, Finland
- Department of Clinical Radiology, Kuopio University Hospital, 70211 Kuopio, Finland
Mia Tapiola
- Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
Susanna Tervo
- Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
Miia Kivipelto
- Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
Tuomo Hänninen
- Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
- Department of Neurology, Kuopio University Hospital, 70211 Kuopio, Finland
Maija Pihlajamäki
- Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
- Department of Neurology, Kuopio University Hospital, 70211 Kuopio, Finland
Mikko P. Laakso
- Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
- Department of Clinical Radiology, Kuopio University Hospital, 70211 Kuopio, Finland
Merja Hallikainen
- Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
Anne Hämäläinen
- Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
Matti Vanhanen
- Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
Eeva-Liisa Helkala
- Department of Public Health, University of Kuopio, 70211 Kuopio, Finland
Ritva Vanninen
- Department of Clinical Radiology, Kuopio University Hospital, 70211 Kuopio, Finland
Aulikki Nissinen
- National Institute of Public Health, Mannerheimintie 116, 00300 Helsinki, Finland
Roberta Rossi
- LENITEM, IRCCS San Giovanni di Dio-FBF, Brescia, Italy
Giovanni B. Frisoni
- LENITEM, IRCCS San Giovanni di Dio-FBF, Brescia, Italy
Hilkka Soininen
- Department of Neuroscience and Neurology, University of Kuopio, Brain Research Unit, Clinical Research Center, Mediteknia, 70211 Kuopio, Finland
- Department of Neurology, Kuopio University Hospital, 70211 Kuopio, Finland

Received 13 April 2006; received in revised form 16 August 2006; accepted 15 September 2006. published online 15 November 2006.

Abstract

The concept of mild cognitive impairment (MCI) has been proposed to represent a transitional stage between normal aging and dementia. We studied the predictive value of the MRI-derived volumes of medial temporal lobe (MTL) structures, white matter lesions (WML), neuropsychological tests, and Apolipoprotein E (APOE) genotype on conversion of MCI to dementia and AD. The study included 60 subjects with MCI identified from population cohorts. During the mean follow-up period of 34 months, 13 patients had progressed to dementia (9 to Alzheimer's disease (AD)). In Cox regression analysis the baseline volumes of the right hippocampus, the right entorhinal cortex and CDR sum of boxes predicted the progression of MCI to dementia during the follow-up. In a bivariate analysis, only the baseline volumes of entorhinal cortex predicted conversion of MCI to AD. The Mini-Mental State Examination (MMSE) score at baseline, WML load, or APOE genotype were not significant predictors of progression. The MTL volumetry helps in identifying among the MCI subjects a group, which is at high risk for developing AD.

Keywords: Alzheimer's disease, Entorhinal cortex, Hippocampus, MRI, Memory, Mild cognitive impairment, White matter lesions, Volumetry, Follow-up study, APOE