Neurobiology of Aging
Volume 28, Issue 5 , Pages 687-688 , May 2007

Spine tingling polymorphisms—Is apolipoprotein E involved in dendritic shape and plasticity?

  • Tara L. Spires
    • ,
  • Bradley T. Hyman

      Affiliations

    • Corresponding Author InformationCorresponding author at: 114, 16th Street, Charlestown, MA 02129, United States. Tel.: +1 617 726 2299; fax: +1 617 724 1480.

Received 4 May 2006 ,Accepted 7 May 2006.

References 

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  2. Holtzman D, Pitas R, Kilbridge J, Nathan B, Mahley R, Bu G, et al. Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. PNAS. 1995;92(21):9480–9484
  3. Ji Y, Gong Y, Gan W, Beach T, Holtzman DM, Wisniewski T. Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients. Neuroscience. 2003;122(2):305–315
  4. Lanz TA, Carter DB, Merchant KM. Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype. Neurobiol Dis. 2003;13(3):246–253
  5. Nathan BP, Jiang Y, Wong GK, Shen F, Brewer GJ, Struble RG. Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein. Brain Res. 2002;928(1–2):96–105
  6. Qiu Z, Hyman BT, Rebeck GW. Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons. J Biol Chem. 2004;279(33):34948–34956
  7. Rebeck GW, Kindy M, LaDu MJ. Apolipoprotein E and Alzheimer's disease: the protective effects of ApoE2 and E3. J Alzheimers Dis. 2002;4(3):145–154
  8. Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance MA, Joo SH, et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology. 1993;43(8):1467–1472
  9. Teter B. ApoE-dependent plasticity in Alzheimer's disease. J Mol Neurosci. 2004;23(3):167–179

PII: S0197-4580(06)00333-2

doi: 10.1016/j.neurobiolaging.2006.05.038

Neurobiology of Aging
Volume 28, Issue 5 , Pages 687-688 , May 2007

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