Neurobiology of Aging
Volume 28, Issue 5 , Pages 707-712 , May 2007

Plasma β amyloid and impaired CO2-induced cerebral vasomotor reactivity

  • Ewoud J. van Dijk

      Affiliations

    • Department of Epidemiology and Biostatistics, Erasmus MC, Erasmus University Medical Center, PO Box 1738, 3000 Rotterdam, The Netherlands
    • Department of Neurology, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands
    • ,
  • Niels D. Prins

      Affiliations

    • Department of Epidemiology and Biostatistics, Erasmus MC, Erasmus University Medical Center, PO Box 1738, 3000 Rotterdam, The Netherlands
    • Department of Neurology, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands
    • ,
  • Albert Hofman

      Affiliations

    • Department of Epidemiology and Biostatistics, Erasmus MC, Erasmus University Medical Center, PO Box 1738, 3000 Rotterdam, The Netherlands
    • ,
  • Cornelia M. van Duijn

      Affiliations

    • Department of Epidemiology and Biostatistics, Erasmus MC, Erasmus University Medical Center, PO Box 1738, 3000 Rotterdam, The Netherlands
    • ,
  • Peter J. Koudstaal

      Affiliations

    • Department of Neurology, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands
    • ,
  • Monique M.B. Breteler

      Affiliations

    • Department of Epidemiology and Biostatistics, Erasmus MC, Erasmus University Medical Center, PO Box 1738, 3000 Rotterdam, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31 10 4087489; fax: +31 10 4089382.

Received 31 August 2005 ,Revised 8 March 2006 ,Accepted 31 March 2006.

References 

  1. Bakker SL, de Leeuw FE, de Groot JC, Hofman A, Koudstaal PJ, Breteler MM. Cerebral vasomotor reactivity and cerebral white matter lesions in the elderly. Neurology. 1999;52:578–583
  2. Bales KR, Verina T, Dodel RC, Du Y, Altstiel L, Bender M, et al. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nat Genet. 1997;17:263–264
  3. Bass A, Krupski WC, Schneider PA, Otis SM, Dilley RB, Bernstein EF. Intraoperative transcranial Doppler: limitations of the method. J Vasc Surg. 1989;10:549–553
  4. Bots ML, van Swieten JC, Breteler MM, de Jong PT, van Gijn J, Hofman A, et al. Cerebral white matter lesions and atherosclerosis in the Rotterdam Study. Lancet. 1993;341:1232–1237
  5. Crawford F, Suo Z, Fang C, Mullan M. Characteristics of the in vitro vasoactivity of beta-amyloid peptides. Exp Neurol. 1998;150:159–168
  6. DeMattos RB, Bales KR, Cummins DJ, Paul SM, Holtzman DM. Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science. 2002;295:2264–2267
  7. DeMattos RB, Bales KR, Parsadanian M, O’Dell MA, Foss EM, Paul SM, et al. Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease. J Neurochem. 2002;81:229–236
  8. Dumville J, Panerai RB, Lennard NS, Naylor AR, Evans DH. Can cerebrovascular reactivity be assessed without measuring blood pressure in patients with carotid artery disease?. Stroke. 1998;29:968–974
  9. Gray F, Dubas F, Roullet E, Escourolle R. Leukoencephalopathy in diffuse hemorrhagic cerebral amyloid angiopathy. Ann Neurol. 1985;18:54–59
  10. Greenberg SM, Rebeck GW, Vonsattel JP, Gomez-Isla T, Hyman BT. Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy. Ann Neurol. 1995;38:254–259
  11. Hetzel A, Braune S, Guschlbauer B, Dohms K. CO2 reactivity testing without blood pressure monitoring?. Stroke. 1999;30:398–401
  12. Hofman A, Grobbee DE, de Jong PT, van den Ouweland FA. Determinants of disease and disability in the elderly: the Rotterdam Elderly Study. Eur J Epidemiol. 1991;7:403–422
  13. Holtzman DM, Fagan AM, Mackey B, Tenkova T, Sartorius L, Paul SM, et al. Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model. Ann Neurol. 2000;47:739–747
  14. Jensen M, Schroder J, Blomberg M, Engvall B, Pantel J, Ida N, et al. Cerebrospinal fluid A beta42 is increased early in sporadic Alzheimer's disease and declines with disease progression. Ann Neurol. 1999;45:504–511
  15. Mehta PD, Pirttila T, Patrick BA, Barshatzky M, Mehta SP. Amyloid beta protein 1–40 and 1–42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease. Neurosci Lett. 2001;304:102–106
  16. Niwa K, Kazama K, Younkin L, Younkin SG, Carlson GA, Iadecola C. Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein. Am J Physiol Heart Circ Physiol. 2002;283:H315–H323
  17. Paulson OB, Strandgaard S, Edvinsson L. Cerebral autoregulation. Cerebrovasc Brain Metab Rev. 1990;2:161–192
  18. Ringelstein EB, Sievers C, Ecker S, Schneider PA, Otis SM. Noninvasive assessment of CO2-induced cerebral vasomotor response in normal individuals and patients with internal carotid artery occlusions. Stroke. 1988;19:963–969
  19. Ruitenberg A, den Heijer T, Bakker SL, van Swieten JC, Koudstaal PJ, Hofman A, et al. Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study. Ann Neurol. 2005;57:789–794
  20. Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med. 1996;2:864–870
  21. Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001;81:741–766
  22. Thomas T, Thomas G, McLendon C, Sutton T, Mullan M. Beta-amyloid-mediated vasoactivity and vascular endothelial damage. Nature. 1996;380:168–171
  23. Tokuda T, Fukushima T, Ikeda S, Sekijima Y, Shoji S, Yanagisawa N, et al. Plasma levels of amyloid beta proteins Abeta1–40 and Abeta1–42(43) are elevated in Down's syndrome. Ann Neurol. 1997;41:271–273
  24. van Dijk EJ, Prins ND, Vermeer SE, Hofman A, van Duijn CM, Koudstaal PJ, et al. Plasma amyloid beta, apolipoprotein E, lacunar infarcts, and white matter lesions. Ann Neurol. 2004;55:570–575
  25. Vinters HV. Cerebral amyloid angiopathy. A critical review. Stroke. 1987;18:311–324
  26. Weller RO, Massey A, Newman TA, Hutchings M, Kuo YM, Roher AE. Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. Am J Pathol. 1998;153:725–733
  27. Wenham PR, Price WH, Blandell G, Apolipoprotein . E genotyping by one-stage PCR. Lancet. 1991;337:1158–1159
  28. Yamauchi H, Fukuyama H, Nagahama Y, Shiozaki T, Nishizawa S, Konishi J, et al. Brain arteriolosclerosis and hemodynamic disturbance may induce leukoaraiosis. Neurology. 1999;53:1833–1838

PII: S0197-4580(06)00110-2

doi: 10.1016/j.neurobiolaging.2006.03.011

Neurobiology of Aging
Volume 28, Issue 5 , Pages 707-712 , May 2007

Article Tools

* Image Usage & Resolution