Neurobiology of Aging
Volume 28, Issue 4 , Pages 519-523 , April 2007

A TAP2 genotype associated with Alzheimer's disease in APOE4 carriers

  • María J. Bullido

      Affiliations

    • Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    • ,
  • Ana Martínez-García

      Affiliations

    • Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    • These authors contributed equally to this work.
    • ,
  • María J. Artiga

      Affiliations

    • Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    • These authors contributed equally to this work.
    • ,
  • Jesús Aldudo

      Affiliations

    • Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    • ,
  • Isabel Sastre

      Affiliations

    • Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    • ,
  • Pedro Gil

      Affiliations

    • Servicio de Geriatría, Hospital Clínico de San Carlos, 28003 Madrid, Spain
    • ,
  • Francisco Coria

      Affiliations

    • 07014 Palma de Mallorca, Spain
    • ,
  • David G. Muñoz

      Affiliations

    • University of Toronto & St. Michael's Hospital, Toronto, Canada
    • ,
  • Vladimir Hachinski

      Affiliations

    • University of Western Ontario, London, Canada
    • ,
  • Ana Frank

      Affiliations

    • Servicio de Neurología, Hospital Universitario La Paz (UAM), 28034 Madrid, Spain
    • ,
  • Fernando Valdivieso

      Affiliations

    • Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    • Corresponding Author InformationCorresponding author. Tel.: +34 91 497 84 71; fax: +34 91 497 48 70.

Received 2 December 2005 ,Revised 16 February 2006 ,Accepted 18 February 2006.

References 

  1. Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Neurobiol Aging. 1997;18(4 Suppl):S1–S2
  2. Bauer D, Tampe R. Herpes viral proteins blocking the transporter associated with antigen processing TAP—from genes to function and structure. Curr Top Microbiol Immunol. 2002;269:87–99
  3. Bertram L, Tanzi RE. Alzheimer's disease: one disorder, too many genes?. Hum Mol Genet. 2004;13 Spec(1):R135–R141
  4. Bertram L, Tanzi RE. The genetic epidemiology of neurodegenerative disease. J Clin Invest. 2005;115(6):1449–1457
  5. Bullido MJ, Artiga MJ, Recuero M, Sastre I, Garcia MA, Aldudo J, et al. A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia. Nat Genet. 1998;18(1):69–71
  6. Burgos JS, Ramirez C, Sastre I, Bullido MJ, Valdivieso F. Involvement of apolipoprotein E in the hematogenous route of herpes simplex virus type 1 to the central nervous system. J Virol. 2002;76(23):12394–12398
  7. Burgos JS, Ramirez C, Sastre I, Bullido MJ, Valdivieso F. apoE4 is more efficient than E3 in brain access by herpes simplex virus type 1. Neuroreport. 2003;14(14):1825–1827
  8. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993;261(5123):921–923
  9. Daniel S, Caillat-Zucman S, Hammer J, Bach JF, van Endert PM. Absence of functional relevance of human transporter associated with antigen processing polymorphism for peptide selection. J Immunol. 1997;159(5):2350–2357
  10. Djilali-Saiah I, Benini V, Daniel S, Assan R, Bach JF, Caillat-Zucman S. Linkage disequilibrium between HLA class II (DR, DQ, DP) and antigen processing (LMP, TAP, DM) genes of the major histocompatibility complex. Tissue Antigens. 1996;48(2):87–92
  11. Fratiglioni L, De Ronchi D, Aguero-Torres H. Worldwide prevalence and incidence of dementia. Drugs Aging. 1999;15(5):365–375
  12. Itzhaki RF, Dobson CB, Shipley SJ, Wozniak MA. The role of viruses and of APOE in dementia. Ann NY Acad Sci. 2004;1019:15–18
  13. Lambert JC, Goumidi L, Vrieze FW, Frigard B, Harris JM, Cummings A, et al. The transcriptional factor LBP-1c/CP2/LSF gene on chromosome 12 is a genetic determinant of Alzheimer's disease. Hum Mol Genet. 2000;9(15):2275–2280
  14. Laws SM, Hone E, Gandy S, Martins RN. Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription. J Neurochem. 2003;84(6):1215–1236
  15. McCluskey J, Rossjohn J, Purcell AW. TAP genes and immunity. Curr Opin Immunol. 2004;16(5):651–659
  16. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34(7):939–944
  17. Wilson HS, Skodol A. Special report: DSM-IV: overview and examination of major changes. Arch Psychiatr Nurs. 1994;8(6):340–347

PII: S0197-4580(06)00080-7

doi: 10.1016/j.neurobiolaging.2006.02.011

Neurobiology of Aging
Volume 28, Issue 4 , Pages 519-523 , April 2007

Article Tools