Neurobiology of Aging
Volume 28, Issue 4 , Pages 519-523, April 2007

A TAP2 genotype associated with Alzheimer's disease in APOE4 carriers

  • María J. Bullido

      Affiliations

    • Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    • ,
  • Ana Martínez-García

      Affiliations

    • Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    • These authors contributed equally to this work.
    • ,
  • María J. Artiga

      Affiliations

    • Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    • These authors contributed equally to this work.
    • ,
  • Jesús Aldudo

      Affiliations

    • Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    • ,
  • Isabel Sastre

      Affiliations

    • Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    • ,
  • Pedro Gil

      Affiliations

    • Servicio de Geriatría, Hospital Clínico de San Carlos, 28003 Madrid, Spain
    • ,
  • Francisco Coria

      Affiliations

    • 07014 Palma de Mallorca, Spain
    • ,
  • David G. Muñoz

      Affiliations

    • University of Toronto & St. Michael's Hospital, Toronto, Canada
    • ,
  • Vladimir Hachinski

      Affiliations

    • University of Western Ontario, London, Canada
    • ,
  • Ana Frank

      Affiliations

    • Servicio de Neurología, Hospital Universitario La Paz (UAM), 28034 Madrid, Spain
    • ,
  • Fernando Valdivieso

      Affiliations

    • Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    • Corresponding Author InformationCorresponding author. Tel.: +34 91 497 84 71; fax: +34 91 497 48 70.

Received 2 December 2005; received in revised form 16 February 2006; accepted 18 February 2006. published online 03 April 2006.

Abstract 

Sporadic Alzheimer's disease (AD) appears to be the consequence of the interaction between combinations of genes and environmental factors. Binding with the transporter associated with antigen processing (TAP) is thought to be the main way in which herpes simplex virus type 1 (HSV-1) evades immune surveillance. Several TAP gene polymorphisms were examined and a TAP2 SNP (rs241448) associated with AD found in two independent case–control samples, especially in carriers of the APOE4 allele. These findings are consistent with the hypothesis that human genetic variants facilitating the access of HSV-1 to the brain might result in susceptibility to AD.

Keywords: Alzheimer's disease, Genetic risk factor, TAP, APOE, Interaction

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PII: S0197-4580(06)00080-7

doi:10.1016/j.neurobiolaging.2006.02.011

Neurobiology of Aging
Volume 28, Issue 4 , Pages 519-523, April 2007

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