Neurobiology of Aging
Volume 28, Issue 4 , Pages 515-518 , April 2007

The leukocyte expression of CD36 is low in patients with Alzheimer's disease and mild cognitive impairment

  • M. Giunta

      Affiliations

    • Center of Excellence on Neurodegenerative Diseases (CEND), Department of Medical Pharmacology, University of Milan, and Centro Dino Ferrari, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
  • ,
  • A.E. Rigamonti

      Affiliations

    • Center of Excellence on Neurodegenerative Diseases (CEND), Department of Medical Pharmacology, University of Milan, and Centro Dino Ferrari, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
  • ,
  • E. Scarpini

      Affiliations

    • Department of Neurological Sciences, University of Milan, and Centro Dino Ferrari, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
  • ,
  • D. Galimberti

      Affiliations

    • Department of Neurological Sciences, University of Milan, and Centro Dino Ferrari, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
  • ,
  • S.M. Bonomo

      Affiliations

    • Center of Excellence on Neurodegenerative Diseases (CEND), Department of Medical Pharmacology, University of Milan, and Centro Dino Ferrari, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
  • ,
  • E. Venturelli

      Affiliations

    • Department of Neurological Sciences, University of Milan, and Centro Dino Ferrari, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
  • ,
  • E.E. Müller

      Affiliations

    • Center of Excellence on Neurodegenerative Diseases (CEND), Department of Medical Pharmacology, University of Milan, and Centro Dino Ferrari, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
  • ,
  • S.G. Cella

      Affiliations

    • Center of Excellence on Neurodegenerative Diseases (CEND), Department of Medical Pharmacology, University of Milan, and Centro Dino Ferrari, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    • Corresponding Author InformationCorresponding author at: Department of Medical Pharmacology, University of Milan, via Vanvitelli 32, 20129 Milan, Italy. Tel.: +39 02 50317015; fax: +39 02 50317011.

Received 4 November 2005 ,Revised 3 January 2006 ,Accepted 9 February 2006.

References 

  1. Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, et al. Inflammation and Alzheimer's disease. Neurobiol Aging. 2000;21:383–421
  2. Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology. 1992;42:631–639
  3. Christie RH, Freeman M, Hyman BT. Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease. Am J Pathol. 1996;148:399–403
  4. Coraci IS, Husemann J, Berman JW, Hulette C, Dufour JH, Campanella GK, et al. CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. Am J Pathol. 2002;160:101–112
  5. Dawe B, Procter A, Philpot M. Concepts of mild cognitive impairment in the elderly and their relationship to dementia: a review. Int J Geriatr Psychiatry. 1992;7:473–479
  6. El Khoury J, Hickman SE, Thomas CA, Cao L, Silverstein SC, Loike JD. Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils. Nature. 1996;382:716–719
  7. Endemann G, Stanton LW, Madden KS, Bryant CM, White RT, Protter AA. CD36 is a receptor for oxidized low density lipoprotein. J Biol Chem. 1993;268:11811–11816
  8. Flicker C, Ferris SH, Reisberg B. Mild cognitive impairment in the elderly: predictors of dementia. Neurology. 1991;41:1006–1009
  9. Folstein MF, Folstein SE, McHugh PR. Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189–198
  10. Gauthier S, Touchon J. Mild cognitive impairment is not a clinical entity and should not be treated. Arch Neurol. 2005;62:1164–1166
  11. Hori T, Nakashima T, Take S, Kaizuka Y, Mori T, Katafuchi T. Related Immune cytokines and regulation of body temperature, food intake and cellular immunity. Brain Res Bull. 1991;27:309–313
  12. Husemann J, Silverstein SC. Expression of scavenger receptor class B, type I, by astrocytes and vascular smooth muscle cells in normal adult mouse and human brain and in Alzheimer's disease brain. Am J Pathol. 2001;158:825–832
  13. Jack CR, Petersen RC, Xu YC, O’Brien PC, Smith GE, Ivnik RJ, et al. Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology. 1999;52:1397–1403
  14. Maxeiner H, Husemann J, Thomas CA, Loike JD, El Khoury J, Silverstein SC. Complementary roles for scavenger receptor A and CD36 of human monocyte-derived macrophages in adhesion to surfaces coated with oxidized low-density lipoproteins and in secretion of H2O2. J Exp Med. 1998;188:2257–2265
  15. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology. 1984;34:939–944
  16. Medeiros LA, Khan T, El Khoury JB, Pham CL, Hatters DM, Howlett GJ, et al. Fibrillar amyloid protein present in atheroma activates CD36 signal transduction. J Biol Chem. 2004;279:10643–10648
  17. Moore KJ, El Khoury J, Medeiros LA, Terada K, Geula C, Luster AD, et al. A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid. J Biol Chem. 2002;277:47373–47379
  18. Morris JC, Storandt M, Miller JP, McKeel DW, Price JL, Rubin EH, et al. Mild cognitive impairment represents early-stage Alzheimer's disease. Arch Neurol. 2001;58:397–405
  19. Ohgami N, Nagai R, Ikemoto M, Arai H, Miyazaki A, Hakamata H, et al. CD36 serves as a receptor for advanced glycation endproducts (AGE). J Diabetes Complications. 2002;16:56–59
  20. Petersen RC, Smith GE, Ivnik RJ, Tangalos EG, Schaid DJ, Thibodeau SN, et al. Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals. JAMA. 1995;273:1274–1278
  21. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999;56:303–308
  22. Petersen RC. Normal aging, mild cognitive impairment, and early Alzheimer's disease. Neurologist. 1995;1:326–344
  23. Ricciarelli R, D’Abramo C, Zingg JM, Giliberto L, Markesbery W, Azzi A, et al. CD36 overexpression in human brain correlates with beta-amyloid deposition but not with Alzheimer's disease. Free Radic Biol Med. 2004;36:1018–1024
  24. Rigamonti AE, Bonomo SM, Scanniffio D, Cella SG, Muller EE. Orexigenic effects of GHS and nitric oxide in aged rats: correlation with the hypothalamic expression of some neuropeptidergic/receptoral effectors mediating food-intake. J Gerontol, in press.
  25. Schlageter NL, Carson RE, Rapoport SI. Examination of blood–brain barrier permeability in dementia of the Alzheimer type with [68Ga]EDTA and positron emission tomography. J Cereb Blood Flow Metab. 1987;7:1–8
  26. Shah Y, Tangalos EG, Petersen RC. Mild cognitive impairment: when is it a precursor to Alzheimer's disease?. Geriatrics. 2000;55:62–68
  27. Sunderland T, Gur RE, Arnold SE. The use of biomarkers in the elderly: current and future challenges. Biol Psychiatry. 2005;58:272–276
  28. Yamada Y, Doi T, Hamakubo T, Kodama T. Scavenger receptor family proteins: roles for atherosclerosis, host defence and disorders of the central nervous system. Cell Mol Life Sci. 1998;54:628–640

PII: S0197-4580(06)00046-7

doi: 10.1016/j.neurobiolaging.2006.02.002

Neurobiology of Aging
Volume 28, Issue 4 , Pages 515-518 , April 2007