Neurobiology of Aging
Volume 28, Issue 3 , Pages 404-413 , March 2007

Mild cognitive impairment (MCI) and actual retrieval performance affect cerebral activation in the elderly

  • Reinhard Heun

      Affiliations

    • Department of Psychiatry, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany
    • Department of Psychiatry, University of Birmingham, Mindelsohn Way, Birmingham B15 2QZ, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 121 678 2360; fax: +44 121 678 2351.
  • ,
  • Katrin Freymann

      Affiliations

    • Department of Psychiatry, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany
  • ,
  • Michael Erb

      Affiliations

    • Section on Experimental Magnetic Resonance of CNS, Department of Neuroradiology, University of Tuebingen, Hoppe-Seyler-Strasse 3, D-72076 Tuebingen, Germany
  • ,
  • Dirk T. Leube

      Affiliations

    • Department of Psychiatry, University of Tuebingen, Osianderstrasse 24, 72076 Tuebingen, Germany
  • ,
  • Frank Jessen

      Affiliations

    • Department of Psychiatry, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany
  • ,
  • Tilo T. Kircher

      Affiliations

    • Department of Psychiatry, University of Tuebingen, Osianderstrasse 24, 72076 Tuebingen, Germany
    • Department of Psychiatry, RWTH Aachen University Hospital, Pauwelstr. 30, D-52074 Aachen, Germany
  • ,
  • Wolfgang Grodd

      Affiliations

    • Section on Experimental Magnetic Resonance of CNS, Department of Neuroradiology, University of Tuebingen, Hoppe-Seyler-Strasse 3, D-72076 Tuebingen, Germany

Received 5 August 2005 ,Revised 16 January 2006 ,Accepted 27 January 2006.

References 

  1. Backman L, Andersson JL, Nyberg L, Winblad B, Nordberg A, Almkvist O. Brain regions associated with episodic retrieval in normal aging and Alzheimer's disease. Neurology. 1999;52:1861–1870
  2. Baschek IL, Bredenkamp J, Oehrle B, Wippich W. Bestimmung der Bildhaftigkeit (I), Konkretheit (C) und der Bedeutungshaltigkeit (m′) von 800 Substantiven. Z Exp Angew Psycho. 1977;25:353–396
  3. Becker JT, Mintun MA, Aleva K, Wiseman MB, Nichols T, DeKosky ST. Compensatory reallocation of brain resources supporting verbal episodic memory in Alzheimer's disease. Neurology. 1996;46:692–700
  4. Bennett DA, Wilson RS, Schneider JA, Evans DA, Beckett LA, Aggarwal NT, et al. Natural history of mild cognitive impairment in older persons. Neurology. 2002;59:198–205
  5. Buckner RL, Koutstaal W, Schacter DL, Dale AM, Rotte M, Rosen BR. Functional-anatomic study of episodic retrieval. II. Selective averaging of event-related fMRI trials to test the retrieval success hypothesis. Neuroimage. 1998;7:163–175
  6. Buckner RL, Koutstaal W, Schacter DL, Wagner AD, Rosen BR. Functional-anatomic study of episodic retrieval using fMRI. I. Retrieval effort versus retrieval success. Neuroimage. 1998;7:151–162
  7. Busse A, Aurich C, Zaudig M, Riedel-Heller S, Matschinger H, Angermeyer MC. Alters- und bildungsspezifische Normierung des kognitiven Tests des SIDAM (Strukturiertes Interview zur Diagnose der Demenz vom Alzheimer-Typ, Multiinfarkt-Demenz und Demenzen anderer Ätiologie nach DSM-IV und ICD-10). Z Geronto Geriatrie. 2002;35:565–574
  8. Cabeza R. Hemispheric asymmetry reduction in older adults: the HAROLD model. Psychol Aging. 2002;17:85–100
  9. Cabeza R, Anderson ND, Locantore JK, McIntosh AR. Aging gracefully: compensatory brain activity in high-performing older adults. Neuroimage. 2002;17:1394–1402
  10. Cabeza R, Daselaar SM, Dolcos F, Prince SE, Budde M, Nyberg L. Task-independent and task-specific age effects on brain activity during working memory, visual attention and episodic retrieval. Cereb Cortex. 2004;14:364–375
  11. Cabeza R, Dolcos F, Prince SE, Rice HJ, Weissman DH, Nyberg L. Attention-related activity during episodic memory retrieval: a cross-function fMRI study. Neuropsychology. 2003;41:390–399
  12. Chetelat G, Desgranges B, de la Sayette V, Viader F, Berkouk K, Landeau B, et al. Dissociating atrophy and hypometabolism impact on episodic memory in mild cognitive impairment. Brain. 2003;126:1955–1967
  13. Daselaar SM, Rombouts SA, Veltman DJ, Raaijmakers JG, Lazeron RH, Jonker C. Parahippocampal activation during successful recognition of words: a self-paced event-related fMRI study. Neuroimage. 2001;13:1113–1120
  14. Daselaar SM, Veltman DJ, Rombouts SA, Raaijmakers JG, Jonker C. Neuroanatomical correlates of episodic encoding and retrieval in young and elderly subjects. Brain. 2003;126:43–56
  15. Daselaar SM, Veltman DJ, Rombouts SA, Raaijmakers JG, Jonker C. Deep processing activates the medial temporal lobe in young but not in old adults. Neurobiol Aging. 2003;24:1005–1011
  16. Desgranges B, Baron JC, Lalevee C, Giffard B, Viader F, de La Sayette V, et al. The neural substrates of episodic memory impairment in Alzheimer's disease as revealed by FDG-PET: relationship to degree of deterioration. Brain. 2002;125:1116–1124
  17. Dickerson BC, Salat DH, Bates JF, Atiya M, Killiany RJ, Greve DN, et al. Medial temporal lobe function and structure in mild cognitive impairment. Ann Neurol. 2004;56:27–35
  18. Dickerson BC, Salat DH, Greve DN, Chua EF, Rand-Giovannetti E, Rentz DM, et al. Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology. 2005;65(3):404–411
  19. Elgh E, Larsson A, Eriksson S, Nyberg L. Altered prefrontal brain activity in persons at risk for Alzheimer's disease: an fMRI study.. Int Psychogeriatr. 2003;15:121–133
  20. Folstein MF, Folstein SE, McHugh PR. “Mini-Mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiat Res. 1975;12:189–198
  21. Good CD, Johnsrude I, Ashburner J, Henson RNA, Friston KJ, Frackowiak RSJ. Cerebral asymmetry and the effects of sex and handedness on brain structure: a voxel-based morphometric analysis of 465 normal adult human brains. Neuroimage. 2001;14:685–700
  22. Grady CL, Maura LF, Pietro P, Barry H, Stanley IR. Altered brain functional connectivity and impaired short-term in Alzeihmer's disease. Brain. 2001;124:739–756
  23. Green DM, Swets JA. Signal detection theory and psychophysics. New York: Wiley; 1966;
  24. Helmstaedter C, Lendt M, Lux S. VMLT-Verbaler Lern- und Merkfähigkeitstest. Beltz: Weinheim; 2001;
  25. Heun R, Freymann N, Granath DO, Stracke CP, Jessen F, Barkow K, et al. Differences of cerebral activation between superior and inferior learners during motor sequence encoding and retrieval. Psychiat Res. 2004;132(1):19–32
  26. Heun R, Jessen F, Klose U, Erb M, Granath DO, Grodd W. Response-related fMRI of veridical and false recognition of words. Eur Psychiat. 2004;19:42–52
  27. Heun R, Kölsch H, Jessen F. Risk factors and early signs of Alzheimer's disease in a family study sample. Eur. Arch. Psychiatr. Clin. Neurosci. 2006;256:28–36
  28. Heun R, Jessen F, Klose U, Erb M, Granath D-O, Grodd W. Response-related fMRI analysis during encoding and retrieval revealed differences in cerebral activation by retrieval success. Psychiat Res, Neuroimaging. 2000;99:137–150
  29. Johnson SC, Saykin AJ, Baxter LC, Flashman LA, Santulli RB, McAllister TW, et al. The relationship between fMRI activation and cerebral atrophy: comparison of normal aging and Alzheimer disease. Neuroimage. 2000;11:179–187
  30. Kato T, Knopman D, Liu H. Dissociation of regional activation in mild AD during visual encoding: a functional MRI study. Neurology. 2001;57:812–816[59]
  31. Konishi S, Wheeler ME, Donaldson DI, Buckner RL. Neural correlates of episodic retrieval success. Neuroimage. 2000;12:276–286
  32. Kopelman MD, Stevens TG, Foli S, Grasby P. PET activation of the medial temporal lobe in learning. Brain. 1998;121:875–887
  33. Logan JM, Sanders AL, Snyder AZ, Morris JC, Buckner RL. Under-recruitment and nonselective recruitment: dissociable neural mechanisms associated with aging. Neuron. 2002;33(5):827–840
  34. Machulda MM, Ward HA, Borowski B, Gunter JL, Cha RH, O’Brien PC, et al. Comparison of memory fMRI response among normal, MCI, and Alzheimer's patients. Neurology. 2003;61(4):500–506
  35. Mandzia J, Black S, Grady C, McAndrews MP, Graham S. Encoding and retrieval in aging and memory loss, a fMRI study. Brain Cogn. 2002;49:225–228
  36. Miezin FM, Maccotta L, Ollinger JM, Petersen SE, Buckner RL. Characterizing the hemodynamic response: effects of presentation rate, sampling procedure, and the possibility of ordering brain activity based on relative timing. Neuroimage. 2000;11(6 Pt. 1):735–759
  37. Nyberg L, Marklund P, Persson J, Cabeza R, Forkstam C, Petersson KM, et al. Common prefrontal activations during working memory, episodic memory, and semantic memory. Neuropsychology. 2003;41:371–377
  38. Nyberg L, McIntosh AR, Houle S, Nilsson LG, Tulving E. Activation of medial temporal structures during episodic memory retrieval. Nature. 1996;380:715–717
  39. Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychology. 1971;9:97–113
  40. Oldigs-Kerber J, Adamus WS, Kitzinger M. Zur Beeinflussung von verbalen Lern- und Gedächtnisprozessen durch Anticholinergica am Beispiel von Scopolamin. Ein pharmakopsychologischer Beitrag für die neuropsychologische Praxis. Z NeuroPsychol. 1991;2:29–40
  41. Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, Rabins PV, et al. Current concepts of mild cognitive impairment. Arch Neurol. 2001;58:1985–1992
  42. Ranganath C, Johnson MK, D’Esposito M. Prefrontal activity associated with working memory and episodic long-term memory. NeuroPsychology. 2003;41:378–389
  43. Remy F, Mirrashed F, Campbell B, Richter W. Verbal episodic memory impairment in Alzheimer's disease: a combined structural and functional MRI study. Neuroimage. 2005;25:253–266
  44. Reuter-Lorenz P. New visions of the aging mind and brain. Trends Cogn Sci. 2002;6:394–400
  45. Rombouts SA, Barkhof F, Goekoop R, Stam CJ, Scheltens P. Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: an fMRI study. Hum Brain Mapp. 2005;26(4):231–239
  46. Rombouts SA, Barkhof F, Veltman DJ, Machielsen WC, Witter MP, Bierlaagh MA, et al. Functional MR imaging in Alzheimer's disease during memory encoding. Am J Neuroradiol. 2000;21(10):1869–1875
  47. Rombouts SA, Goekoop R, Stam CJ, Barkhof F, Scheltens P. Delayed rather than decreased BOLD response as a marker for early Alzheimer's disease. Neuroimage. 2005;26(4):1078–1085
  48. Rugg MD, Fletcher PC, Frith CD, Frackowiak RS, Dolan RJ. Differential activation of the prefrontal cortex in successful and unsuccessful memory retrieval. Brain. 1996;119:2073–2083
  49. Saykin AJ, Flashman LA, Frutiger SA, Johnson SC, Mamourian AC, Moritz CH, et al. Neuroanatomic substrates of semantic memory impairment in Alzheimer's disease: patterns of functional MRI activation. J Int Neuropsychol Soc. 1999;5:377–392
  50. Saykin AJ, Wishart HA. Mild cognitive impairment: conceptual issues and structural and functional brain correlates. Semin Clin Neuropsychiat. 2003;8:12–30
  51. Schacter DL, Buckner RL, Koutstaal W, Dale AM, Rosen BR. Late onset of anterior prefrontal activity during true and false recognition: an event-related fMRI study. Neuroimage. 1997;6:259–269
  52. Tulving E, Habib R, Nyberg L, Lepage M, McIntosh AR. Positron emission tomography correlations in and beyond medial temporal lobes. Hippocampus. 1999;9:71–82
  53. Wheeler ME, Buckner RL. Functional-anatomic correlates of remembering and knowing. Neuroimage. 2004;21(4):1337–1349
  54. World Health Organization . In: Tenth Revision of the International Classification of Diseases. Chapter V (F): Mental and Behavioural Disorders (including disorders of psychological development). Clinical Descriptions and Diagnostic Guidelines. WHO; 1991;

PII: S0197-4580(06)00042-X

doi: 10.1016/j.neurobiolaging.2006.01.012

Neurobiology of Aging
Volume 28, Issue 3 , Pages 404-413 , March 2007