Neurobiology of Aging
Volume 28, Issue 3 , Pages 351-356 , March 2007

Expression of cortical and hippocampal apoptosis-inducing factor (AIF) in aging and Alzheimer's disease

  • Stéphanie Reix

      Affiliations

    • Institut de Neurobiologie de la Méditerranée (INMED), Institut National de la Santé et de la Recherche Médicale (INSERM), Parc Scientifique Luminy, BP13, 13 273 Marseille, France
    • Douglas Hospital Research Centre, Department of Psychiatry, McGill University, 6875 LaSalle Blvd, Verdun (Montréal), Qc, Canada H4H 1R3
    • These authors contributed equally to the study.
    • ,
  • Naguib Mechawar

      Affiliations

    • Douglas Hospital Research Centre, Department of Psychiatry, McGill University, 6875 LaSalle Blvd, Verdun (Montréal), Qc, Canada H4H 1R3
    • These authors contributed equally to the study.
    • Corresponding Author InformationCorresponding author. Tel.: +1 514 761 6131x2825; fax: +1 514 762 3034.
    • ,
  • Santos A. Susin

      Affiliations

    • Apoptose et Système Immunitaire, Centre de Recherche Scientifique (CNRS)-URA 1961, Institut Pasteur, 25 rue du Dr Roux, 75 015 Paris, France
    • ,
  • Rémi Quirion

      Affiliations

    • Douglas Hospital Research Centre, Department of Psychiatry, McGill University, 6875 LaSalle Blvd, Verdun (Montréal), Qc, Canada H4H 1R3
    • ,
  • Slavica Krantic

      Affiliations

    • Institut de Neurobiologie de la Méditerranée (INMED), Institut National de la Santé et de la Recherche Médicale (INSERM), Parc Scientifique Luminy, BP13, 13 273 Marseille, France

Received 22 August 2005 ,Revised 8 December 2005 ,Accepted 21 January 2006.

References 

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  6. Joza N, Susin SA, Daugas E, Stanford WL, Cho SK, Li CY, et al. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 2001;410(6828):549–554
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  9. Krantic S, Mechawar N, Reix S, Quirion R. Molecular basis of programmed cell death involved in neurodegeneration. Trends Neurosci. 2005;28(12):670–676
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  13. Rego AC, Oliveira CR. Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases. Neurochem Res. 2003;28(10):1563–1574
  14. Susin S, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, et al. Molecular characterization of mitochondrial apoptosis inducing factor. Nature. 1999;397(6718):441–446
  15. Vahsen N, Cande C, Briere JJ, Benit P, Joza N, Larochette N, et al. AIF deficiency compromises oxidative phosphorylation. EMBO J. 2004;23(23):4679–4689
  16. Wang H, Yu SW, Koh DW, Lew J, Coombs C, Bowers W, et al. Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal cell death. J Neurosci. 2004;24(48):10963–10973
  17. Yuan J, Lipinski M, Degterev A. Diversity in the mechanisms of neuronal cell death. Neuron. 2003;40(2):401–413
  18. Yuste VJ, Moubarak RS, Delettre C, Bras M, Sancho P, d’Alayer J, et al. Cysteine protease inhibition prevents mitochondrial apoptosis-inducing factor (AIF) release. Cell Death Differ. 2005;12(11):1445–1448
  19. Zhang X, Chen J, Graham SH, Du L, Kochanek PM, Draviam R, et al. Intranuclear localization of apoptosis-inducing factor (AIF) and large scale DNA fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite. J Neurochem. 2002;82(1):181–191

☆ All authors have read the paper and state that this is material not previously published and not being considered for publication elsewhere. None of us has any conflict of interest whatsoever with regards to the presented work, which was approved by the Douglas Hospital Research Ethics Board (Montreal, Canada) and supported by grants from CIHR (RQ) and CNRS-CIHR (SK), a joint grant from INSERM-FRSQ (RQ and SK) and a postdoctoral fellowship to NM from FRSQ and the Alzheimer Society of Canada.

PII: S0197-4580(06)00008-X

doi: 10.1016/j.neurobiolaging.2006.01.003

Neurobiology of Aging
Volume 28, Issue 3 , Pages 351-356 , March 2007

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