Neurobiology of Aging
Volume 27, Issue 12 , Pages 1740-1750 , December 2006

siRNA targeted against amyloid precursor protein impairs synaptic activity in vivo

  • A.S. Hérard

      Affiliations

    • CEA-CNRS URA 2210, Service Hospitalier Frédéric Joliot, 4, Place du Général Leclerc, F-91401 Orsay Cedex, France
    • MIRCen, 18, Route du Panorama, F-92265 Fontenay-Aux-Roses Cedex, France
    • ,
  • L. Besret

      Affiliations

    • CEA-CNRS URA 2210, Service Hospitalier Frédéric Joliot, 4, Place du Général Leclerc, F-91401 Orsay Cedex, France
    • ,
  • A. Dubois

      Affiliations

    • CEA-UIIBP, Service Hospitalier Frédéric Joliot, 4, Place du Général Leclerc, F-91401 Orsay Cedex, France
    • ,
  • J. Dauguet

      Affiliations

    • CEA-UIIBP, Service Hospitalier Frédéric Joliot, 4, Place du Général Leclerc, F-91401 Orsay Cedex, France
    • ,
  • T. Delzescaux

      Affiliations

    • CEA-UIIBP, Service Hospitalier Frédéric Joliot, 4, Place du Général Leclerc, F-91401 Orsay Cedex, France
    • ,
  • P. Hantraye

      Affiliations

    • CEA-CNRS URA 2210, Service Hospitalier Frédéric Joliot, 4, Place du Général Leclerc, F-91401 Orsay Cedex, France
    • CEA-UIIBP, Service Hospitalier Frédéric Joliot, 4, Place du Général Leclerc, F-91401 Orsay Cedex, France
    • MIRCen, 18, Route du Panorama, F-92265 Fontenay-Aux-Roses Cedex, France
    • ,
  • G. Bonvento

      Affiliations

    • CEA-CNRS URA 2210, Service Hospitalier Frédéric Joliot, 4, Place du Général Leclerc, F-91401 Orsay Cedex, France
    • These authors contributed equally to this work.
    • Corresponding Author InformationCorresponding author.
    • ,
  • K.L. Moya

      Affiliations

    • CEA-CNRS URA 2210, Service Hospitalier Frédéric Joliot, 4, Place du Général Leclerc, F-91401 Orsay Cedex, France
    • These authors contributed equally to this work.
    • Corresponding Author InformationCorresponding author. Present address: CNRS UMR 8542, Ecole Normale Supérieure, 46, rue d’Ulm, 75231 Paris Cedex 05, France. Tel.: +33 1 44 32 37 19; fax: +33 1 44 32 23 23.

Received 30 June 2005 ,Revised 7 October 2005 ,Accepted 20 October 2005.

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PII: S0197-4580(05)00343-X

doi: 10.1016/j.neurobiolaging.2005.10.020

Neurobiology of Aging
Volume 27, Issue 12 , Pages 1740-1750 , December 2006

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