Neurobiology of Aging
Volume 27, Issue 12 , Pages 1733-1739 , December 2006

Peripheral clearance of amyloid β peptide by complement C3-dependent adherence to erythrocytes

  • Joseph Rogers

      Affiliations

    • L.J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P.O. Box 1278, Sun City, AZ 85372, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 623 876 5328; fax: +1 623 876 5461.
    • ,
  • Rena Li

      Affiliations

    • L.J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P.O. Box 1278, Sun City, AZ 85372, USA
    • ,
  • Diego Mastroeni

      Affiliations

    • L.J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P.O. Box 1278, Sun City, AZ 85372, USA
    • ,
  • Andrew Grover

      Affiliations

    • L.J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P.O. Box 1278, Sun City, AZ 85372, USA
    • ,
  • Brian Leonard

      Affiliations

    • L.J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P.O. Box 1278, Sun City, AZ 85372, USA
    • ,
  • Geoffrey Ahern

      Affiliations

    • Department of Neurology, University of Arizona College of Medicine, P.O. Box 245070, Tuscon, AZ 85724, USA
    • ,
  • Phillip Cao

      Affiliations

    • L.J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P.O. Box 1278, Sun City, AZ 85372, USA
    • ,
  • Heather Kolody

      Affiliations

    • L.J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P.O. Box 1278, Sun City, AZ 85372, USA
    • ,
  • Linda Vedders

      Affiliations

    • L.J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P.O. Box 1278, Sun City, AZ 85372, USA
    • ,
  • William P. Kolb

      Affiliations

    • Advanced Research Technology, 5230 Carrol Canyon Road, Suite 110, San Diego, CA 92121, USA
    • ,
  • Marwan Sabbagh

      Affiliations

    • L.J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P.O. Box 1278, Sun City, AZ 85372, USA

Received 27 September 2005 ,Accepted 29 September 2005.

References 

  1. Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, et al. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med. 2000;6(8):916–919
  2. Bradt BM, Kolb WP, Cooper NR. Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide. J Exp Med. 1998;188(3):431–438
  3. Cooper NR, Jensen FC, Welsh RM, Oldstone MB. Lysis of RNA tumor viruses by human serum: direct antibody-independent triggering of the classical complement pathway. J Exp Med. 1976;144(4):970–984
  4. DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA. 2001;98(15):8850–8855
  5. Geslani DM, Tierney MC, Herrmann N, Szalai JP. Mild cognitive impairment: an operational definition and its conversion rate to Alzheimer's disease. Dement Geriatr Cogn Disord. 2005;19(5–6):383–389
  6. Ghiso J, Shayo M, Calero M, Ng D, Tomidokoro Y, Gandy S, et al. Systemic catabolism of Alzheimer's Abeta40 and Abeta42. J Biol Chem. 2004;279(44):45897–45908
  7. Hess C, Schifferli JA. Immune adherence revisited: novel players in an old game. News Physiol Sci. 2003;18:104–108
  8. Jiang H, Burdick D, Glabe CG, Cotman CW, Tenner AJ. Beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. J Immunol. 1994;152(10):5050–5059
  9. Johnson KJ, Ward PA. Biology of disease Newer concepts in the pathogenesis of immune complex-induced tissue injury. Lab Invest. 1982;47(3):218–226
  10. Dr. John W. Kimball, c2005. Kimball's Biology Pages [Internet]. Andover, MA, available at http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/.
  11. Kuo YM, Kokjohn TA, Kalback W, Luehrs D, Galasko DR, Chevallier N, et al. Amyloid-beta peptides interact with plasma proteins and erythrocytes: implications for their quantitation in plasma. Biochem Biophys Res Commun. 2000;268(3):750–756
  12. Masliah E, Hansen L, Adame A, Crews L, Bard F, Lee C, et al. Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease. Neurology. 2005;64(1):129–131
  13. Mayeux R, Tang MX, Jacobs DM, Manly J, Bell K, Merchant C, et al. Plasma amyloid beta-peptide 1–42 and incipient Alzheimer's disease. Ann Neurol. 1999;46(3):412–416
  14. Mehta PD, Pirttila T, Mehta SP, Sersen EA, Aisen PS, Wisniewski HM. Plasma and cerebrospinal fluid levels of amyloid beta proteins 1–40 and 1–42 in Alzheimer disease. Arch Neurol. 2000;57(1):100–105
  15. Mok W, Chow TW, Zheng L, Mack WJ, Miller C. Clinicopathological concordance of dementia diagnoses by community versus tertiary care clinicians. Am J Alzheimers Dis Other Demen. 2004;19(3):161–165
  16. Nelson RA. The immune-adherence phenomenon; an immunologically specific reaction between microorganisms and erythrocytes leading to enhanced phagocytosis. Science. 1953;118(3077):733–737
  17. Rogers J, Cooper NR, Webster S, Schultz J, McGeer PL, Styren SD, et al. Complement activation by beta-amyloid in Alzheimer disease. Proc Natl Acad Sci USA. 1992;89(21):10016–10020
  18. Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature. 1999;400(6740):173–177
  19. Schifferli JA, Ng YC, Paccaud JP, Walport MJ. The role of hypocomplementaemia and low erythrocyte complement receptor type 1 numbers in determining abnormal immune complex clearance in humans. Clin Exp Immunol. 1989;75(3):329–335
  20. Tamaoka A, Fukushima T, Sawamura N, Ishikawa K, Oguni E, Komatsuzaki Y, et al. Amyloid beta protein in plasma from patients with sporadic Alzheimer's disease. J Neurol Sci. 1996;141(1–2):65–68
  21. Taylor RP, Martin EN, Reinagel ML, Nardin A, Craig M, Choice Q, et al. Bispecific monoclonal antibody complexes facilitate erythrocyte binding and liver clearance of a prototype particulate pathogen in a monkey model. J Immunol. 1997;159(8):4035–4044
  22. Watson DM, Roher AE, Kim KS, Spiegel K, Emmerling MR. Complement labeling of aggregated Aβ1–42 by normal human serum involves the classical and alternative pathways. In:  Iqbal K,  Winblad B,  Nishimura T,  Takeda M,  Wisniewski HM editor. Alzheimer's disease: biology, diagnostics and therapeutics. Hoboken: John Wiley and Sons; 1997;p. 365–373
  23. Webster S, Bradt B, Rogers J, Cooper N. Aggregation state-dependent activation of the classical complement pathway by the amyloid beta peptide. J Neurochem. 1997;69(1):388–398

PII: S0197-4580(05)00313-1

doi: 10.1016/j.neurobiolaging.2005.09.043

Neurobiology of Aging
Volume 27, Issue 12 , Pages 1733-1739 , December 2006

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