Peripheral clearance of amyloid β peptide by complement C3-dependent adherence to erythrocytes

Rogers, Joseph; Li, Rena; Mastroeni, Diego; Grover, Andrew; Leonard, Brian; Ahern, Geoffrey; Cao, Phillip; Kolody, Heather; Vedders, Linda; Kolb, William P.; Sabbagh, Marwan

doi:10.1016/j.neurobiolaging.2005.09.043

« Previous Next »Neurobiology of Aging
Volume 27, Issue 12 , Pages 1733-1739, December 2006

Peripheral clearance of amyloid β peptide by complement C3-dependent adherence to erythrocytes

Joseph Rogers
- L.J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P.O. Box 1278, Sun City, AZ 85372, USA
- Corresponding author. Tel.: +1 623 876 5328; fax: +1 623 876 5461.
Rena Li
- L.J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P.O. Box 1278, Sun City, AZ 85372, USA
Diego Mastroeni
- L.J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P.O. Box 1278, Sun City, AZ 85372, USA
Andrew Grover
- L.J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P.O. Box 1278, Sun City, AZ 85372, USA
Brian Leonard
- L.J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P.O. Box 1278, Sun City, AZ 85372, USA
Geoffrey Ahern
- Department of Neurology, University of Arizona College of Medicine, P.O. Box 245070, Tuscon, AZ 85724, USA
Phillip Cao
- L.J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P.O. Box 1278, Sun City, AZ 85372, USA
Heather Kolody
- L.J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P.O. Box 1278, Sun City, AZ 85372, USA
Linda Vedders
- L.J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P.O. Box 1278, Sun City, AZ 85372, USA
William P. Kolb
- Advanced Research Technology, 5230 Carrol Canyon Road, Suite 110, San Diego, CA 92121, USA
Marwan Sabbagh
- L.J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P.O. Box 1278, Sun City, AZ 85372, USA

Received 27 September 2005; accepted 29 September 2005. published online 15 November 2005.

Abstract

Brain deposits of amyloid β peptide (Aβ) have been a diagnostic hallmark of Alzheimer's disease (AD) for nearly a century. Recent studies have demonstrated that Aβ is also present in peripheral blood. Here, we present evidence that circulating Aβ42 is subject to complement C3b-dependent adherence to complement receptor 1 (CR1) on erythrocytes, a classical set of mechanisms by which pathogens and proteins recognized as foreign are cleared from the bloodstream. Levels of Aβ42 targeted by this pathway differ significantly in AD compared to mild cognitive impairment and nondemented elderly controls.

Keywords: Amyloid β peptide, Complement, Alzheimer's disease, Blood, Clearance