Neurobiology of Aging
Volume 27, Issue 10 , Pages 1431-1434, October 2006

Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Porter Neuroscience Building, 35 Convent Drive, Bethesda, MD 20892 3707, USA

Received 30 June 2005; received in revised form 3 August 2005; accepted 26 August 2005. published online 04 October 2005.

Abstract 

We have initiated a systematic analysis of the role of cholesterol metabolizing genes as risk factors for Alzheimer's disease pathogenesis. As part of this analysis, we have assessed the NR1H2 gene on chromosome 19 and report here a modest association with the locus in sibpairs with late onset disease.

Keywords: Alzheimer's disease, Genetics, Cholesterol, LXR gene

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PII: S0197-4580(05)00239-3

doi:10.1016/j.neurobiolaging.2005.08.010

Neurobiology of Aging
Volume 27, Issue 10 , Pages 1431-1434, October 2006

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