« Previous
Next »
Neurobiology of Aging
Volume 26, Issue 1,
Supplement
, Pages 65-69
, December 2005
Insulin resistance syndrome and Alzheimer's disease: Age- and obesity-related effects on memory, amyloid, and inflammation
References
- . Insulin transport from plasma into the central nervous system is inhibited by dexamethasone in dogs. Diabetes. 1996;45(1):86–90
- The role of insulin in human brain glucose metabolism: an 18fluoro-deoxyglucose positron emission tomography study. Diabetes. 2002;51(12):3384–3390
- Insulin dose–response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype. Psychoneuroendocrinology. 2003;28(6):809–822
- . Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype. Neurology. 1998;50(1):164–168
- . Insulin and neurodegenerative disease: shared and specific mechanisms. Lancet Neurol. 2004;3(3):169–178
- . The anti-inflammatory and potential anti-atherogenic effect of insulin: a new paradigm. Diabetologia. 2002;45(6):924–930
- . The metabolic syndrome. Lancet. 2005;365(9468):1415–1428
- Hyperinsulinemia provokes synchronous increases in central inflammation and β-amyloid in normal adults. Arch Neurol. 2005;62(10):1539–1544
- Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. J Neurosci. 2001;21(8):2561–2570
- Systemic catabolism of Alzheimer's Abeta40 and Abeta42. J Biol Chem. 2004;279(44):45897–45908
- Glial-neuronal interactions in Alzheimer's disease: the potential role of a ‘cytokine cycle’ in disease progression. Brain Pathol. 1998;8(1):65–72
- . Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs. Diabetes. 2000;49(9):1525–1533
- Plasma A[beta]40 and A[beta]42 and Alzheimer's disease: relation to age, mortality, and risk. Neurology. 2003;61(9):1185–1190
- . Intracerebroventricular insulin enhances memory in a passive-avoidance task. Physiol Behav. 2000;68(4):509–514
- Reger MA, Watson GS, Frey WH, 2nd, Baker LD, Cholerton B, Keeling ML, et al. Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype. Neurobiol Aging, in press.
- . Beta-amyloid-(1-42) impairs activity-dependent cAMP-response element-binding protein signaling in neurons at concentrations in which cell survival is not compromised. J Biol Chem. 2001;276(20):17301–17306
- Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus. Brain Res. 2002;924(2):133–140
- Watson GS, Cholerton B, Reger MA, Baker LD, Plymate S, Asthana S, et al. Preserved cognition during rosiglitazone treatment in early Alzheimer's disease. Am J Geriatr Psychiatry, in press.
- Insulin increases CSF Abeta42 levels in normal older adults. Neurology. 2003;60(12):1899–1903
- The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J Neurosci. 2002;22(5):1858–1867
- Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention. J Neurosci. 2004;24(49):11120–11126
PII: S0197-4580(05)00230-7
doi: 10.1016/j.neurobiolaging.2005.08.021
« Previous
Next »
Neurobiology of Aging
Volume 26, Issue 1,
Supplement
, Pages 65-69
, December 2005
