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Neurobiology of Aging
Volume 27, Issue 10
, Pages 1440-1444
, October 2006
Genetic variation in the choline acetyltransferase (CHAT) gene may be associated with the risk of Alzheimer's disease
References
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- Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science. 2000;290:2302–2303
- Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study. Am J Med Genet (B Neuropsychiatr Genet). 2005;132:5–8
- Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science. 2000;290:2303–2304
- Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease. Hum Genet. 2003;113:258–267
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- Choline acetyltransferase G
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4 A polymorphism confers a risk for Alzheimer's disease in concert with Apolipoprotein E epsilon4. Neurosci Lett. 2004;366:182–186 - . The interaction of selection and linkage I: general considerations, hetorotic models. Genetics. 1964;49:49–67
- Age at onset in two common neurodegenerative diseases is genetically controlled. Am J Hum Genet. 2002;70:985–993
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- . Identification of a single nucleotide polymorphism in the choline acetyltransferase gene associated with Alzheimer's disease. Neurosci Lett. 2002;333:9–12
- Full genome screen for Alzheimer disease: stage II analysis. Am J Med Genet. 2002;114:235–244
- . Choline acetyltransferase: the structure, distribution and pathologic changes in the central nervous system. Pathol Int. 1999;49:921–937
- Lack of association between a single nucleotide polymorphism within the choline acetyltransferase gene and patients with Alzheimer's disease. Neurosci Lett. 2003;343:167–170
- . Apolipoprotein E epsilon 4 allele and the lifetime risk of Alzheimer's disease. What physicians know, and what they should know. Arch Neurol. 1995;52:1074–1079
- Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study. Arch Neurol. 1998;55:964–968
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PII: S0197-4580(05)00228-9
doi: 10.1016/j.neurobiolaging.2005.08.024
© 2005 Elsevier Inc. All rights reserved.
« Previous
Next »
Neurobiology of Aging
Volume 27, Issue 10
, Pages 1440-1444
, October 2006
