Neurobiology of Aging
Volume 27, Issue 10 , Pages 1425-1430 , October 2006

ApoE gene and familial risk of Alzheimer's disease as predictors of odour identification in older adults

  • Olivia J. Handley

      Affiliations

    • School of Psychology, Cardiff University, UK
    • Corresponding Author InformationCorresponding author at: School of Biosciences, Museum Avenue, Cardiff University, Cardiff CF10 3US, UK. Tel.: +44 29 2087 5197; fax: +44 29 2087 6749.
  • ,
  • Catriona M. Morrison

      Affiliations

    • Institute of Psychological Sciences, University of Leeds, UK
  • ,
  • Christopher Miles

      Affiliations

    • School of Psychology, Cardiff University, UK
  • ,
  • Antony J. Bayer

      Affiliations

    • University Department of Geriatric Medicine, Cardiff University, UK

Received 13 May 2005 ,Revised 26 July 2005 ,Accepted 3 August 2005.

References 

  1. Allen SJ. Alzheimer's disease: past, present, and future themes. In:  Dawbarn D,  Allen SJ editor. Neurobiology of Alzheimer's disease. 2nd ed.. Oxford: OUP; 2001;p. 1–32
  2. Bacon AW, Bondi MW, Salmon DP, Murphy C. Very early changes in olfactory functioning due to Alzheimer's disease and the role of apolipoprotein E in olfaction. Ann NY Acad Sci. 1998;855:723–731
  3. Berg L, McKeel DW, Miller JP, Storandt M, Rubin EH, Morris JC, et al. Clinicopathological studies in cognitively healthy aging and Alzheimer disease: relation of histologic markers to dementia severity, age, sex, and Apolipoprotein E genotype. Arch Neurol. 2003;55:326–335
  4. Berr C, Lambert JC, Sazdovitch V, Amouyel P, Chartier-Harlin MC, Mohr M, et al. Neuropathological epidemiology of cerebral aging: a study of two genetic polymorhisms. Neurobiol Aging. 2001;22:227–235
  5. Bondi MW, Monsch AU, Galasko D, Butters N, Salmon DP, Delis DC. Preclinical cognitive markers of dementia of the Alzheimer type. Neuropsychology. 1994;8:374–384
  6. Boss MA. Diagnostic approaches to Alzheimer's disease. Biochim Biophys Acta. 2000;1502:188–200
  7. Braak H, Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol. 1991;82:239–259
  8. Corder EH, Saunders AM, Risch NJ, Strittmatter WJ, Schmechel DE, Gaskell PCJ , et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer's disease. Nat Gen. 1994;7:180–184
  9. Devanand DP, Michaels-Marston KS, Liu X, Pelton GH, Padilla M, Marder K, et al. Olfactory deficits in patients with mild cognitive impairment predict Alzheimer's disease at follow-up. Am J Psychiatry. 2000;157:1399–1405
  10. Doty RL. Odour perception in neurodegenerative diseases. In:  Doty RL editors. Handbook of olfaction and gustation. 2nd ed.. NY: Marcel Dekker; 2003;p. 479–503
  11. Eichenbaum H, Morton TH, Potter H, Corkin S. Selective olfactory deficits in case HM. Brain. 1983;106:459–472
  12. Folstein MF, Folstein S, McHugh PR. Mini-Mental State Exam: a practical method for grading the status of patients for clinicians. J Psychiatr Res. 1975;12:189–198
  13. Fox NC, Warrington EK, Seiffer AL, Agnew SK, Rossor MN. Presymptomatic cognitive deficits in individuals at risk of familial Alzheimer's disease. Brain. 1998;121:1631–1639
  14. Gilbert P, Murphy C. The effect of the ApoE epsilon4 allele on recognition memory for olfactory and visual stimuli in patients with pathologically confirmed Alzheimer's disease, probable Alzheimer's disease, and healthy elderly controls. J Clin Exp Neuropsychol. 2004;26:779–794
  15. Gilbert PE, Barr PJ, Murphy C. Differences in olfactory and visual memory in patients with pathologically confirmed Alzheimer's disease and the Lewy body variant of Alzheimer's disease. J Int Neuropsychol Soc 2004;10:835–42.
  16. Graves AB, Bowen JD, Rajaram L, McCormick WC, McCurry SM, Schellenberg GD, et al. Impaired olfaction as a marker for cognitive decline: interaction with apolipoprotein E epsilon4 status. Neurology. 1999;53:1480–1487
  17. Hardy J. New insights into the genetics of Alzheimer's disease. Trends Mol Med. 1996;28:255–258
  18. Hixson JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with Hhal. J Lipid Res. 1990;31:545–548
  19. Kim KW, Younm JC, Lee DY, Lee KU, Lee JH, Woo JI. Apolipoprotein E e4 allele is not associated with the cognitive impairment in community-dwelling normal elderly individuals. Int J Geriatr Psychiatry. 2002;17:635–640
  20. Kovács T, Cairns NJ, Lantos PL. Amyloid deposition and neurofibrilliary tangle formation in the olfactory bulb in ageing and Alzheimer's disease. Neuropathol Appl Neurobiol. 1999;25:481–491
  21. Larsson M, Finkel D, Pedersen NL. Odor identification: Influences of age, gender, cognition, and personality. J Gerontol. 2000;55B:P304–P310
  22. Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 1988;240:622–630
  23. Mayeux R, Small SA, Tang M-X, Tycko B, Stern Y. Memory performance in healthy elderly without Alzheimer's disease: effects of time and apolipoprotein-E. Neurobiol Aging. 2001;22:683–689
  24. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939–944
  25. Mesholam RI, Moberg PJ, Mahr RN, Doty RL. Olfaction in neurodegenerative disease. Arch Neurol. 1998;55:84–90
  26. Morgan CD, Nordin S, Murphy C. Odour identification as an early marker for Alzheimer's disease: Impact of lexical functioning and detection sensitivity. J Clin Exp Neuropsychol. 1995;17:793–803
  27. Murphy C. Loss of olfactory function in dementing disease. Physiol Behav. 1999;66:177–182
  28. Murphy C, Bacon AW, Bondi M, Salmon DP. Apolipoprotein E status is associated with odour identification deficits in nondemented older persons. Ann NY Acad Sci. 1998;855:744–750
  29. Murphy C, Schubert CR, Cruickshanks KJ, Klein BEK , Klein R, Nondahl DM. Prevalence of olfactory impairment in older adults. J Am Med Assoc. 2002;288:2307–2312
  30. Nicolli-Waller C, Harvey J, Nordin S, Murphy C. Remote odour memory in Alzheimer's disease: deficits as measured by familiarity. J Adult Dev. 1999;6:131–137
  31. Nilsson L, Nyberg L, Bäckman L. Genetic variation in memory functioning. Neurosci Biobehav Rev. 2002;26:841–848
  32. Ohm TG, Kirca M, Bohl J, Scharnagl H, Groß W, März W. Apolipoprotein E polymorphism influences not only cerebral senile plaque load but also Alzheimer-type neurofibrillary tangle formation. Neuroscience. 1995;66:583–587
  33. Ott A, Breteler MMB, van Harskamp F, Claus JJ, van der Cammen TJM, Grobbee DE, et al. Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam study. Br Med J. 1995;31:970–973
  34. Pericak-Vance M, Grubber J, Bailey LR, Hedges D, West S, Santoro L, et al. Identification of novel genes in late-onset Alzheimer's disease. Exp Gerontol. 2000;35:1343–1352
  35. Pericak-Vance M, Bebout JL, Gaskell J, Yamaoka LH, Hung WY, Alberts MJ, et al. Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage. Am J Hum Genet. 1991;48:1034–1050
  36. Peters JM, Hummel T, Kratzsch T, Lotsch J, Skarke C, Frolich L. Olfactory function in mild cognitive impairment and Alzheimer's disease: an investigation using psychophysical and electrophysiological techniques. Am J Psychiatry. 2004;160:1995–2002
  37. Rice F, Abraham R, Rudruasingham V, Owen MJ, Williams J. Memory for new information as a cognitive marker of liability to Alzheimer's disease in a high risk group: research note. Int J Geriatr Psychiatry. 2003;18:155–160
  38. Schiffman SS, Graham BG, Sattely-Miller EA, Zervakis J, Welsh-Bohmer K. Taste, smell and neuropsychological performance of individuals at familial risk for Alzheimer's disease. Neurobiol Aging. 2002;23:397–404
  39. Schmechel DE, Saunders AM, Strittmatter WJ, Crain BJ, Hulette CM, Joo SH, et al. Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer's disease. Proc Natl Acad Sci USA. 1993;90:9649–9653
  40. Serby M, Mohan C, Aryan M, Williams L, Mohs R, Davis KL. Olfactory identification deficits in relatives of Alzheimer's disease patients. Biol Psychiatry. 1996;39:375–377
  41. Small BJ, Graves AB, McEvoy CL, Crawford FC, Mullan M, Mortimer JA. Is ApoE-e4 a risk factor for cognitive impairment in normal aging?. Neurology. 2000;54:2082–2088
  42. Small GW, Chen ST, Komo S, Ercoli L, Bookheimer S, Miller K, et al. Memory self-appraisal in middle-aged and older adults with the apolipoprotein E-4 allele. Am J Psychiatry. 1999;156:1035–1038
  43. Smith GE, Bohac DL, Waring SC, Kokmen E, Tangalos EG, Ivnik RJ, et al. Apolipoprotein E genotype influences cognitive ‘phenotype’ in patients with Alzheimer's disease but not in healthy control subjects. Neurology. 1998;50:355–362
  44. Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, et al. Apolipoprotein E: high-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA. 1993;90:1977–1981
  45. Strittmatter WJ, Weisgraber KH, Huang DY, Dong L, Salvesen G, Pericak-Vance M, et al. Binding of human apolipoprotein E to synthetic amyloid β peptide: isoform-specific effects and implications for late-onset Alzheimer's disease. Proc Natl Acad Sci USA. 1993;90:8098–8102
  46. van Dujin CM, Clayton D, Chandra V, Fratiglioni L, Graves A, Heyman A, et al. Familial aggregation of Alzheimer's disease and related disorders: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group. Int J Epidemiol. 1991;20:13–S20
  47. Wang QS, Tian L, Huang YL, Qin S, He LQ, Zhou JN. Olfactory identification and apolipoprotein E epsilon 4 allele in mild cognitive impairment. Brain Res. 2002;951:77–81

PII: S0197-4580(05)00221-6

doi: 10.1016/j.neurobiolaging.2005.08.001

Neurobiology of Aging
Volume 27, Issue 10 , Pages 1425-1430 , October 2006