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Neurobiology of Aging
Volume 27, Issue 10
, Pages 1435-1439
, October 2006
Alpha-1-antichymotrypsin (ACT or SERPINA3) polymorphism may affect age-at-onset and disease duration of Alzheimer's disease
References
- . Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell. 1988;52:451–487
- The number of trait loci in late-onset Alzheimer disease. Am J Hum Genet. 2000;66:196–204
- Plasma and cerebrospinal fluid α1-antichymotrypsin levels in Alzheimer's disease: correlation with cognitive impairment. Ann Neurol. 2003;53:81–90
- No genetic effect of α1-antichymotrypsin in Alzheimer disease. Genomics. 1996;33:53–56
- Regional cerebral glucose utilization is modulated by the dosage of apolipoprotein E type 4 allele and α1-antichymotrypsin type A allele in Alzheimer disease. Neuroreport. 1997;8:2639–2643
- . The relationship of APOE polymorphism and cholesterol levels in normoglycemic and diabetic subjects in a biethnic population from the San Luis Valley, Colorado. Atherosclerosis. 1995;112:145–159
- . APOE*4-associated Alzheimer's disease risk is modified by α1-antichymotrypsin polymorphism. Nat Genet. 1995;10:486–488
- Apolipoprotein E controls the risk and age at onset of Parkinson disease. Neurology. 2004;62:2005–2009
- Age at onset in two common neurodegenerative diseases is genetically controlled. Am J Hum Genet. 2002;70:985–993
- A new promoter polymorphism in the alpha-1-antichymotrypsin gene is a disease modifier of Alzheimer's disease. Neurobiol Aging. 2005;26:449–453
- Gene polymorphism affecting alpha1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer's disease risk. Ann Neurol. 2000;48:388–391
- Acute phase reactant α1-antichymotrypsin is increased in cerebrospinal fluid and serum of patients with probable Alzheimer's disease. Alzheimer Dis Assoc Disord. 1995;9:112–118
- . Amyloid-associated proteins α1-antitrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments. Nature. 1994;372:92–94
- . Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939–944
- Polymorphism in the alpha(1)-antichymotrypsin (ACT) gene promoter: effect on expression in transfected glial and liver cell lines and plasma ACT concentrations. Hum Genet. 2001;109:303–310
- . Astroglial expression of human α1-antichymotrypsi enhances Alzheimer's –like pathology in amyloid protein precursor transgenic mice. Am J Pathol. 2000;157:2003–2010
- Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation. Neurobiol Aging. 2004;25:1153–1167
- α1-Antichymotrypsin promotes β-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease. J Neurosci. 2001;21:1444–1451
- . Effect of cytokines, dexamethazone and the A/T-signal peptide polymorphism on the expression of alpha1-antichymotrypsin in astrocytes: significance for Alzheimer's disease. Neurochem Int. 2000;39:361–370
- . A second locus for very-late-onset Alzheimer disease: a genome scan reveals linkage to 20p and epistasis between 20p and the amyloid precursor protein region. Am J Hum Genet. 2002;71:154–161
- Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: The Rotterdam Study. Arch Neurol. 1998;55:964–968
- Polymorphism in the AACT gene may lower age of onset of Alzheimer's disease. Neuroreport. 1996;7:534–536
- . Genetic association analysis of alpha-1-antichymotrypsin polymorphism in Parkinson's disease. Eur Neurol. 2001;45:254–256
- Association of alpha1-antichymotrypsin polymorphism with cerebral amyloid angiopathy. Ann Neurol. 1998;44:129–131
- α1-Antichymotrypsin as a risk modifier for late-onset Alzheimer's disease in Japanese apolipoprotein E epsilon 4 carriers. Ann Neurol. 1997;42:115–117
PII: S0197-4580(05)00215-0
doi: 10.1016/j.neurobiolaging.2005.07.015
© 2005 Elsevier Inc. All rights reserved.
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Neurobiology of Aging
Volume 27, Issue 10
, Pages 1435-1439
, October 2006
