Neurobiology of Aging
Volume 27, Issue 10 , Pages 1385-1394 , October 2006

Hippocampal atrophy in the healthy is initially linear and independent of age

Received 4 March 2005 ,Revised 11 July 2005 ,Accepted 21 July 2005.

References 

  1. Aisen P. The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease. Lancet Neurol. 2002;1:279–284
  2. Baxter LC, Caselli RJ, Johnson SC, Reiman E, Osborne D. Apolipoprotein E epsilon4 affects new learning in cognitively normal individuals at risk for Alzheimer's disease. Neurobiol Aging. 2003;24:947–952
  3. Benton A, Hamsher K, Varney N, Spreen O. Contributions to neuropsychological assessment. New York: Oxford Press; 1983;
  4. Bobinski M, de Leon MJ, Wegiel J, Desanti S, Convit A, Saint Louis LA, et al. The histological validation of post mortem magnetic resonance imaging-determined hippocampal volume in Alzheimer's disease. Neuroscience. 2000;95:721–725
  5. Bondi MW, Salmon DP, Butters N. Neuropsychological features of memory disorders in Alzheimer disease. In:  Terry RD,  Katzman R,  Bick KL editor. Alzheimer disease. New York: Raven Press, Ltd.; 1994;p. 41–63
  6. Bondi MW, Salmon DP, Monsch AU, Galasko D, Butters N, Klauber MR, et al. Episodic memory changes are associated with the APOE-epsilon 4 allele in nondemented older adults. Neurology. 1995;45:2203–2206
  7. Borkowski J, Benton A, Spreen OEA. Word fluency and brain damage. Neuropsychologia. 1967;5:135–140
  8. Braak H, Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol Appl Neurobiol. 1991;14:39–44
  9. Buschke H. Selective reminding for analysis of memory anhd learning. J Verbal Learning Verbal Behav. 1973;12:543–550
  10. Chantôme M, Perruchet P, Dominique H, Dormont D, Sahel M, Sourour N, et al. Is There a negative correlation between explicit memory and hippocampal volume. Neuroimage. 1999;10:589–595
  11. Christiansen H, Hadzi-Pavlovic D, Jacomb P. The psychometric differentiation of dementia from normal aging: A meta-analysis. Psychol Assessment. 1991;3:147–155
  12. Cohen RM, Small C, Lalonde F, Friz J, Sunderland T. The effect of apolipoprotein E genotype on hippocampal volume loss in aging healthy women. Neurology. 2001;57:2223–2228
  13. Convit A, De Leon MJ, Tarshish C, De Santi S, Tsui W, Rusinek H, et al. Specific hippocampal volume reductions in individuals at risk for Alzheimer's disease. Neurobiol Aging. 1997;18:131–138
  14. Corp T. Manual for the Wechsler Adult Intelligence Scale. San Antonio, TX: Harcourt Brace Jovanovich, Inc.; 1981;
  15. Corp T. Wechsler Memory Scale-Revised Manual. San Antonio, TX: Harcourt Brace Jovanovich, Inc.; 1987;
  16. de Leon MJ, Convit A, George AE, Golomb J, de Santi S, Tarshish C, et al. In vivo structural studies of the hippocampus in normal aging and in incipient Alzheimer's disease. Ann N Y Acad Sci. 1996;777:1–13
  17. Delis DC, Massman PJ, Butters N, Salmon DP, Kramer JH, Cermank L. Profiles of demented and amnesic patients on the California Verbal Learning Test: Implications for the assessment of memory disorders. Psychol Assess. 1991;3:19–26
  18. Deweer B, Lehericy S, Pillon B, Baulac M, Chiras J, Marsault C, et al. Memory disorders in probable Alzheimer's disease: the role of hippocampal atrophy as shown with MRI. J Neurol Neurosurg Psychiatry. 1995;58:590–597
  19. Du AT, Schuff N, Kramer JH, Ganzer S, Zhu XP, Jagust WJ, et al. Higher atrophy rate of entorhinal cortex than hippocampus in AD. Neurology. 2004;62:422–427
  20. Fox NC, Warrington EK, Freeborough PA, Hartikainen P, Kennedy AM, Stevens JM, et al. Presymptomatic hippocampal atrophy in Alzheimer's disease. A longitudinal MRI study. Brain. 1996;119:2001–2007
  21. Geroldi C, Pihlajamaki M, Laakso MP, DeCarli C, Beltramello A, Bianchetti A, et al. APOE-epsilon4 is associated with less frontal and more medial temporal lobe atrophy in AD. Neurology. 1999;53:1825–1832
  22. Golomb J, Kluger A, de Leon MJ, Ferris SH, Convit A, Mittelman MS, et al. Hippocampal formation size in normal human aging: a correlate of delayed secondary memory performance. Learn Mem. 1994;1:45–54
  23. Gould E, McEwen B, Tanapat P, Galea L, Fuchs E. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci. 1997;17:2492–2498
  24. Grundman MJCJ, Petersen RC, Kim HT, Taylor C, Datvian M, Weiner MF, et al. Alzheimer's Disease Cooperative Study. Hippocampal volume is associated with memory but not monmemory cognitive performance in patients with mild cognitive impairment. J Mol Neurosci. 2004;20:241–248
  25. Hackert VH, den Heijer T, Oudkerk M, Koudstaal PJ, Hofman A, Breteler MM. Hippocampal head size associated with verbal memory performance in nondemented elderly. Neuroimage. 2002;17:1365–1372
  26. Henderson VW. The epidemiology of estrogen replacement therapy and Alzheimer's disease. Neurology. 1997;48:S27–S35
  27. Henderson VW, Paganini-Hill A, Miller BL, Elble RJ, Reyes PF, Shoupe D, et al. Estrogen for Alzheimer's disease in women: randomized, double-blind, placebo-controlled trial. Neurology. 2000;54:295–301
  28. Heun R, Mazanek M, Atzor KR, Tintera J, Gawehn J, Burkart M, et al. Amygdala-hippocampal atrophy and memory performance in dementia of Alzheimer type. Dement Geriatr Cogn Disord. 1997;8:329–336
  29. Hyman BT, van Hoesen GW, Damasio A, Barnes C. Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science. 1984;225:1168–1170
  30. Jack CR, Petersen RC, O’Brien PC, Tangalos EG. MR-based hippocampal volumetry in the diagnosis of Alzheimer's disease. Neurology. 1992;42:183–188
  31. Jack CR, Petersen RC, Xu Y, O’Brien PC, Smith GE, Ivnik RJ, et al. Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease. Neurology. 1998;51:993–999
  32. Jack CR, Petersen RC, Xu YC, O’Brien PC, Smith GE, Ivnik RJ, et al. Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology. 1999;52:1397–1403
  33. Jack CR, Petersen RC, Xu YC, O’Brien PC, Waring SC, Tangalos EG, et al. Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease. Ann Neurol. 1998;43:303–310
  34. Jack CR, Shiung MM, Gunter JL, O’Brien PC, Weigand SD, Knopman DS, et al. Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD. Neurology. 2004;62:591–600
  35. Juottonen K, Laakso MP, Partanen K, Soininen H. Comparative MR analysis of the entorhinal cortex and hippocampus in diagnosing Alzheimer disease. AJNR Am J Neuroradiol. 1999;20:139–144
  36. Juottonen K, Lehtovirta M, Helisalmi S, Riekkinen PJ, Soininen H. Major decrease in the volume of the entorhinal cortex in patients with Alzheimer's disease carrying the apolipoprotein E epsilon4 allele. J Neurol Neurosurg Psychiatry. 1998;65:322–327
  37. Kates WR, Abrams MT, Kaufmann WE, Breiter SN, Reiss AL. Reliability and validity of MRI measurement of the amygdala and hippocampus in children with Fragile X Syndrome. Psychiatry Res: Neuroimag Sect. 1997;75:31–48
  38. Kesslak JP, Nalcioglu O, Cotman CW. Quantification of magnetic resonance scans for hippocampal and parahippocampal atrophy in Alzheimer's disease [see comments]. Neurology. 1991;41:51–54
  39. Killiany RJ, Moss MB, Albert MS, Sandor T, Tieman J, Jolesz F. Temporal lobe regions on magnetic resonance imaging identify patients with early Alzheimer's disease. Arch Neurol. 1993;50:949–954
  40. Kohler S, Black SE, Sinden M, Szekely C, Kidron D, Parker JL, et al. Memory impairments associated with hippocampal versus parahippocampal-gyrus atrophy: an MR volumetry study in Alzheimer's disease [published erratum appears in Neuropsychologia 1999 Jan;37(1):123]. Neuropsychologia. 1998;36:901–914
  41. Krasuski JS, Alexander GE, Horwitz B, Daly EM, Murphy DG, Rapoport SI, et al. Volumes of medial temporal lobe structures in patients with Alzheimer's disease and mild cognitive impairment (and in healthy controls). Biol Psychiatry. 1998;43:60–68
  42. Kril JJ, Hodges J, Halliday G. Relationship between hippocampal volume and CA1 neuron loss in brains of humans with and without Alzheimer's disease. Neurosci Lett. 2004;361:9–12
  43. Laakso MP, Soininen H, Partanen K, Helkala EL, Hartikainen P, Vainio P, et al. Volumes of hippocampus, amygdala and frontal lobes in the MRI-based diagnosis of early Alzheimer's disease: correlation with memory functions. J Neural Transm Park Dis Dement Sect. 1995;9:73–86
  44. Lehericy S, Baulac M, Chiras J, Pierot L, Martin N, Pillon B, et al. Amygdalohippocampal MR volume measurements in the early stages of Alzheimer disease. AJNR Am J Neuroradiol. 1994;15:929–937
  45. Levy JA, Bergeson J, Putnam K, Rosen V, Cohen R, Lalonde F, et al. Context-specific memory and apolipoprotein E (ApoE) epsilon 4: cognitive evidence from the NIMH prospective study of risk for Alzheimer's disease. J Int Neuropsychol Soc. 2004;10:362–370
  46. Mattis S. Dementia rating scale: professional manual. Odessa, FL: Psychological Assessment Resources; 1983;
  47. Moffat SD, Szekely CA, Zonderman AB, Kabani NJ, Resnick SM. Longitudinal change in hippocampal volume as a function of apolipoprotein E genotype. Neurology. 2000;55:134–136
  48. Mortimer JA, Gosche KM, Riley KP, Markesbery WR, Snowdon DA. Delayed recall, hippocampal volume and Alzheimer neuropathology: findings from the Nun Study. Neurology. 2004;62:428–432
  49. Newman SK, Warrington EK, Kennedy AM, Rosser MN. The earliest cognitive change in a person with familial Alzheimer's disease: presymjptomatic neuropsychological features i a pedigree with familial Alzheimer's disease confirmed at necropsy. J Neurol Neurosurg Psychiatry. 1994;57:967–972
  50. O’Brien JT, Desmond P, Ames D, Schweitzer I, Chiu E, Tress B. Temporal lobe magnetic resonance imaging can differentiate Alzheimer's disease from normal ageing, depression, vascular dementia and other causes of cognitive impairment. Psychol Med. 1997;27:1267–1275
  51. Pantel J, Schroder J, Schad LR, Friedlinger M, Knopp MV, Schmitt R, et al. Quantitative magnetic resonance imaging and neuropsychological functions in dementia of the Alzheimer type. Psychol Med. 1997;27:221–229
  52. Petersen R, Jack CRJ, Xu YC, Waring SC, O’Brien PC, Smith GE, et al. Memory and MRI-based hippocampal volumes in aging and AD. Neurology. 2000;54:581–587
  53. Price JL, Ko AI, Wade MJ, Tsou SK, McKeel DW, Morris JC. Neuron number in the entorhinal cortex and CA1 in precllinical Alzheimer disease. Arch Neurol. 2001;58:1395–1402
  54. Raz N, Gunning-Dixon F, Head D, Dupruis J, Acker J. Neuroanatomical correlateds of cognitive aging: Evidence from structural magnetic resonance imaging. 1998;12:95–114
  55. Raz N, Rodrigue KM, Head D, Kennedy KM, Acker JD. Differential aging of the medial temporal lobe: a study of a five-year change. Neurology. 2004;62:433–438
  56. Rössler M, Zarski R, Bohl J, Ohm T. Stage-dependent and sector-specific neuronal loss in hippocampus during Alzheimer's disease. Acta Neuropathol. 2002;103:363–369
  57. Rusinek H, De Santi S, Frid D, Tsui WH, Tarshish CY, Convit A, et al. Regional brain atrophy rate predicts future cognitive decline: 6-year longitudinal MR imaging study of normal aging. Radiology. 2003;229:691–696
  58. Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse [see comments]. Nature. 1999;400:173–177
  59. Schott JM, Fox NC, Frost C, Scahill RI, Janssen JC, Chan D, et al. Assessing the onset of structural change in familial Alzheimer's disease. Ann Neurol. 2003;53:181–188
  60. Sheline Y, Wang P, Gado M, Csernansky J, Vannier M. Hippocampal atrophy in recurrent major depression. 1996;93:3908–3913
  61. Stein M, Koverola C, Hanna C, Torchia M, McClarty B. Hippocampal volume in women victimized by childhood sexual abuse. Psychol Med. 1997;27:951–959
  62. Stout JC, Bondi MW, Jernigan TL, Archibald SL, Delis DC, Salmon DP. Regional cerebral volume loss associated with verbal learning and memory in dementia of the Alzheimer type. Neuropsychology. 1999;13:188–197
  63. Taylor L. Localization of cerebral lesions by psychological testing. Clin Neurosurg. 1969;16:269–287
  64. Tomlinson BE, Blessed G, Roth M. Observations on the brains of demented old people. J Neurol Sci. 1970;11:205–242
  65. Tuszynski MH, Gage FH, Mufson EJ, Kordower JH. Neurotrophic factors, gene therapy, and Alzheimer's disease. In:  Tuszynski MH,  Kordower JH editor. CNS regeneration: basic and clinical advances. San Diego: Academic Press; 1999;p. 505–528
  66. Visser PJ, Scheltens P, Verhey FR, Schmand B, Launer LJ, Jolles J, et al. Medial temporal lobe atrophy and memory dysfunction as predictors for dementia in subjects with mild cognitive impairment. J Neurol. 1999;246:477–485
  67. West M, Kawas C, Stewart W, Rudow G, Troncoso J. Hippocampal neurons in pre-clinical Alzheimer's disease. Neurobiol Aging. 2004;25:1205–1212
  68. West MJ, Coleman PD, Flood DG, Troncoso JC. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet. 1994;344:769–772
  69. Wolozin B, Kellman W, Ruosseau P, Celesia GG, Siegel G. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch Neurol. 2000;57:1439–1443
  70. Wu Y, Delgado R, Costello R, Sunderland T, Dukoff R, Csako G. Quantitative assessment of apolipoprotein E genotypes by image analysis of PCR-RFLP fragments. Clin Chim Acta. 2000;293:213–221
  71. Xu Y, Jack CR, O’Brien PC, Kokmen E, Smith GE, Ivnik RJ, et al. Usefulness of MRI measures of entorhinal cortex versus hippocampus in AD. Neurology. 2000;54:1760–1767
  72. Zhou Q, Homma K, Poo M. Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses. Neuron. 2004;44:749–757

PII: S0197-4580(05)00213-7

doi: 10.1016/j.neurobiolaging.2005.07.018

Neurobiology of Aging
Volume 27, Issue 10 , Pages 1385-1394 , October 2006

Article Tools

* Image Usage & Resolution