« Previous
Next »
Neurobiology of Aging
Volume 27, Issue 7
, Pages 946-954
, July 2006
Deficient cerebral clearance of vasculotropic mutant Dutch/Iowa Double Aß in human AßPP transgenic mice
References
- Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1–42/1–40 ratio in vitro and in vivo. Neuron. 1996;17:1005–1013
- Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene. Nature. 1991;353:844–846
- Mutation of the ß-amyloid precursor protein in familial Alzheimer's disease increases ß-protein production. Nature. 1992;360:672–674
- . Enhanced pathologic properties of Dutch-type mutant amyloid ß-protein. Proc Natl Acad Sci USA. 1996;93:2996–3000
- Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid ß-protein precursor. J Biol Chem. 2004;279:20296–20306
- RAGE mediates amyloid beta-peptide transport across the blood–brain barrier and accumulation in brain. Nat Med. 2003;9:907–913
- LRP-amyloid beta-peptide (Abeta) interaction regulates differential brain efflux of Abeta isoforms. Neuron. 2004;43:333–344
- Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA. 2002;99:10843–10848
- . Fate of cerebrospinal fluid-borne amyloid beta-peptide: rapid clearance into blood and appreciable accumulation by cerebral arteries. J Neurochem. 1996;67:880–883
- Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature. 1991;349:704–706
- . Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy. Ann Neurol. 2001;49:697–705
- Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene. Nat Genet. 1992;1:218–221
- . Alzheimer's disease and cerebrovascular pathology: an update. J Neural Transm. 2002;109:813–836
- Amyloid precursor protein processing and Aß42 deposition in a transgenic mouse model of Alzheimer's disease. Proc Natl Acad Sci USA. 1997;94:1550–1555
- The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology. Nat Med. 1996;2:1146–1150
- Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science. 1990;248:1124–1126
- . Charge alterations of E22 in the amyloid ß-protein enhance its pathogenic properties. J Neurochem. 2000;74:2209–2212
- Substitutions at codon 22 of Alzheimer's Aß peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells. J Biol Chem. 2000;275:27110–27116
- Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood. Neurobiol Aging. 2002;23:405–412
- Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme. J Biol Chem. 2003;278:23221–23226
- A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nat Genet. 1992;1:345–347
- . Distribution of beta/A4 and amyloid precursor protein in hereditary cerebral hemorrhage with amyloidosis-Dutch type and Alzheimer's disease. Am J Pathol. 1993;142:1449–1457
- . Amyloid ß-protein stimulates parallel increases in the cellular levels of its precursor and amyloid precursor-like protein 2 (APLP2) in human cerebrovascular smooth muscle cells. Amyloid. 1997;4:54–60
- . Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001;81:741–766
- Clearance of Alzheimer's amyloid-ß(1–40) peptide from brain by LDL receptor-related protein-1 at the blood–brain barrier. J Clin Invest. 2000;106:1489–1499
- A new BetaPP mutation related to hereditary cerebral haemorrhage. Alzheimer's Rep. 1999;2:S28
- . Parenchymal preamyloid and amyloid deposits in the brains of patients with hereditary cerebral hemorrhage with amyloidosis–Dutch type. Neurosci Lett. 1990;118:223–226
- . Dutch Flemish, Italian, and Arctic mutations in APP and resistance of Abeta to physiologically relevant proteolytic degradation. Lancet. 2003;361:1957–1958
- Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch). Science. 1990;248:1120–1122
- . Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer's disease. Proc Natl Acad Sci USA. 1987;84:5991–5994
- Protease nexin-II, a potent antichymotrypsin, shows identity to the amyloid ß-protein precursor. Nature. 1989;341:546–549
- . Pathologic cell surface amyloid beta-protein fibril assembly in cultured human cerebrovascular smooth muscle cells. J Neurochem. 1997;69:216–223
- . Pathogenic Effects of D23N “Iowa” Amyloid ß-Protein. J Biol Chem. 2001;276:32860–32866
- . Rapid degeneration of cultured human brain pericytes by amyloid beta protein. J Neurochem. 1997;68:1135–1141
- . Cerebral amyloid angiopathy: a critical review. Stroke. 1987;18:311–324
- . Amyloidosis of cerebral arteries. Adv Neurol. 2003;92:105–112
- . Effects of the amyloid precursor protein Glu693>Gln ‘Dutch’ mutation on the production and stability of amyloid beta-protein. Biochem J. 1999;340:703–709
- . Hereditary cerebral haemorrhage with amyloidosis, Dutch type (HCHWA-D): clinicopathological studies. J Neurol Neurosurg Psychiatry. 1995;59:699–705
- . Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. Am J Pathol. 1998;153:725–733
- . Cerebral amyloid angiopathy: accumulation of A beta in interstitial fluid drainage pathways in Alzheimer's disease. Ann NY Acad Sci. 2000;903:110–117
- . Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation. Biochem Biophys Res Commun. 1991;179:1247–1254
- Assembly of hereditary amyloid β-protein variants in the presence of favorable gangliosides. FEBS Lett. 2005;579:2185–2190
PII: S0197-4580(05)00188-0
doi: 10.1016/j.neurobiolaging.2005.05.031
© 2005 Elsevier Inc. All rights reserved.
« Previous
Next »
Neurobiology of Aging
Volume 27, Issue 7
, Pages 946-954
, July 2006
