Neurobiology of Aging
Volume 27, Issue 7 , Pages 941-945 , July 2006

Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia

  • Edmund C. Jenkins

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 718 494 5236; fax: +1 718 494 1026.
    • ,
  • Milen T. Velinov

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    • ,
  • Lingling Ye

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    • ,
  • Hong Gu

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    • ,
  • Shuyun Li

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    • ,
  • Edmund C. Jenkins Jr.

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    • ,
  • Susan Sklower Brooks

      Affiliations

    • Division of Pediatric Genetics, UMDNJ Robert Wood Johnson School of Medicine, New Brunswick, NJ, USA
    • ,
  • Deborah Pang

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    • ,
  • Darlynne A. Devenny

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    • ,
  • Warren B. Zigman

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    • ,
  • Nicole Schupf

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    • Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, NY, USA
    • ,
  • Wayne P. Silverman

      Affiliations

    • New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA

Received 12 November 2003 ,Revised 29 April 2005 ,Accepted 4 May 2005.

References 

  1. Ahmed A, Tollefsbol T. Telomeres and telomerase: basic science implications for aging. J Am Geriatr Soc. 2001;49:1105–1109
  2. Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, et al. Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA. 1992;89:10114–10118
  3. Aylward E, Burt D, Thorpe L, Lai F, Dalton A. Diagnosis of dementia in individuals with intellectual disability. J Intellect Disabil Res. 1997;41:152–164
  4. Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, et al. Accelerated telomere shortening in response to life stress. PNAS. 2004;101(49):17312–17315(Epub 2004 December 7 at www.pnas.org/cgi/doi/10.1073/pnas.0407162101)
  5. Flanary BE, Streit WJ. Telomeres shorten with age in rat cerebellum and cortex in vivo. J Anti-Aging Med. 2003;6:299–308
  6. Hao LY, Strong MA, Greider CW. Phosphorylation of H2AX at short telomeres in T cells and fibroblasts. J Biol Chem. 2004;279(October (43)):45148–45154Epub 2004 August 17
  7. Itagaki S, McGeer PL, Akiyama H. Presence of T cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue. Neurosci Lett. 1988;91:259–264
  8. Lansdorp PM, Verwoerd NP, van de Rijke FM, Dragowska V, Little M-T, Dirks RW, et al. Heterogeneity in telomere length of human chromosomes. Hum Mol Genet. 1996;5:685–691
  9. Londoño-Vallejo JA, DerSarkissian H, Cazes L, Thomas G. Differences in telomere length between homologous chromosomes in humans. Nucleic Acids Res. 2001;29:3164–3171
  10. Olovnikov AM. Principles or marginotomy in template synthesis of polynucleotides. Dokj Akad Nauk SSSR. 1971;201:1496–1499
  11. Panossian LA, Porter VR, Valenzuela HF, Zhu X, Reback E, Masterman D, et al. Telomere shortening in T cells correlates with Alzheimer's status. Neurobiol Aging. 2003;24:77–84
  12. Plentz RR, Caselitz M, Bleck JS, Gebel M, Flemming P, Kubicka S, et al. Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma. Hepatology. 2004;40(1):80–86
  13. Rubin H. The disparity between human cell senescence in vitro and lifelong replication in vivo. Nat Biotechnol. 2002;20:675–681
  14. Schupf N, Pang D, Patel BN, Silverman W, Schubert R, Lai F, et al. Onset of dementia is associated with age at menopause in women with Down syndrome. Ann Neurol. 2003;54:433–438
  15. Silverman W, Schupf N, Zigman W, Devenny D, Miezejeski C, Schubert R, et al. Dementia in adults with mental retardation: assessment at a single point in time. Am J Ment Retard. 2004;109(2):111–125
  16. Strauss D, Eyman R. Mortality of people with mental retardation in California with and without Down syndrome. Am J Mental Retard. 1996;100:643–653
  17. Vaziri H, Schachter F, Uchida I, Wei L, Zhu X, Effros R, et al. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes. Am J Hum Genet. 1993;52:661–667
  18. Watson JD. Origin of concataeric T4 DNA. Nat N Biol. 1972;239:197–201
  19. Zigman WB, Schupf N, Sersen E, Silverman W. Prevalence of dementia in adults with and without Down syndrome. Am J Ment Retard. 1996;100:403–412
  20. Zou Y, Sfeir A, Gryaznov SM, Shay JW, Wright WE. Does a sentinel or a subset of short telomeres determine replicative senescence?. Mol Biol Cell. 2004;15(8):3709–3718Epub 2004 June 4

PII: S0197-4580(05)00171-5

doi: 10.1016/j.neurobiolaging.2005.05.021

Neurobiology of Aging
Volume 27, Issue 7 , Pages 941-945 , July 2006

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