Neurobiology of Aging
Volume 27, Issue 7 , Pages 973-982 , July 2006

Cellular environment facilitates protein accumulation in aged rat hippocampus

Received 13 December 2004 ,Revised 18 April 2005 ,Accepted 13 May 2005.

References 

  1. Araujo F, Ruano D, Vitorica J. Absence of association between delta and gamma 2 subunits in native GABA(A) receptors from rat brain. Eur J Pharmacol. 1998;347:347–353
  2. Araujo F, Tan S, Ruano D, Schoemaker H, Benavides J, Vitorica J. Molecular and pharmacological characterization of native cortical gamma-aminobutyric acid(A) receptors containing both alpha1 and alpha3 subunits. J Biol Chem. 1996;271:27902–27911
  3. Breckenridge D, Germain M, Mathai JP, Nguyen M, Shore G. Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene. 2004;22:8608–8618
  4. Calfon M, Zeng H, Urano F, et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature. 2002;415:92–96
  5. Carrard G, Dieu M, Raes M, Toussaint O, Friguet B. Impact of ageing on proteasome structure and function in human lymphocytes. Int J Biochem Cell Biol. 2003;35:728–739
  6. Caspersen C, Pedersen PS, Treiman M. The sarco/endoplasmic reticulum calcium-ATPase 2b is an endoplasmic reticulum stress-inducible protein. J Biol Chem. 2000;275:22363–22372
  7. de Virgilio M, Weninger H, Ivessa N. J Biol Chem. 1998;273:9734–9743
  8. del Rio JC, Araujo F, Ramos B, Ruano D, Vitorica J. Prevalence between different alpha subunits performing the benzodiazepine binding sites in native heterologous GABA(A) receptors containing the alpha2 subunit. J Neurochem. 2001;79:183–191
  9. Harding HP, Zhang Y, Ron D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature. 1999;397:271–274
  10. Harding HP, Calfon M, Urano F, Novoa I, Ron D. Transcriptional and translational control in the mammalian unfolded protein response. Ann Rev Cell Dev Biol. 2002;18:575–599
  11. Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002;297:353–356
  12. Katayama T, Imaizumi K, Sato N, et al. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response. Nat Cell Biol. 1999;1:479–485
  13. Kaufman RJ. Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev. 1999;13:1211–1233
  14. Keller JN, Gee J, Ding Q. The proteasome in brain aging. Ageing Res Rev. 2002;2:279–293
  15. Keller JN, Hanni KB, Markesbery WR. Impaired proteasome function in Alzheimer's disease. J Neurochem. 2000;75:436–439
  16. Keller JN, Hanni KB, Markesbery WR. Possible involvement of proteasome inhibition in aging: implications for oxidative stress. Mech Ageing Dev. 2000;113:61–70
  17. Keller JN, Huang FF, Markesbery WR. Decreased levels of proteasome activity and proteasome expression in aging spinal cord. Neurosci. 2000;98:149–156
  18. Lenny N, Green M. Regulation of endoplasmic reticulum stress proteins in COS cells transfected with immunoglobulin mu heavy chain cDNA. J Biol Chem. 1991;266:20532–20537
  19. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265–275
  20. McCracken AA, Brodsky JL. Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP. J Cell Biol. 1996;132:291–298
  21. McNaught K, Jenner P. Proteasomal function is impaired in substantia nigra in Parkinson's disease. Neurosci Lett. 2001;297:191–194
  22. Nakagawa T, Zhu H, Morishima N, et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature. 2000;403:98–103
  23. Ng DT, Watowich SS, Lamb RA. Analysis in vivo of GRP78-BiP/substrate interactions and their role in induction of the GRP78-BiP gene. Mol Biol Cell. 1992;3:143–155
  24. Oyadomari S, Mori M. Roles of CHOGADD153 in endoplasmic reticulum stress. Cell Death Differ. 2004;11:381–389
  25. Patil C, Walter P. Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr Opin Cell Biol. 2001;13:349–355
  26. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. San Diego: Academic Press; 1986;
  27. Rao RV, Poksay KS, Castro-Obregon S, et al. Molecular components of a cell death pathway activated by endoplasmic reticulum stress. J Biol Chem. 2004;279:177–187
  28. Rao R, Ellerby H, Bredesen DE. Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ. 2004;11:372–380
  29. Ruano D, Araujo F, Revilla E, Vela J, Bergis O, Vitorica J. GABA(A) and alpha-amino-3-hydroxy-5-methylsoxazole-4-propionate receptors are differentially affected by aging in the rat hippocampus. J Biol Chem. 2000;275:19585–19593
  30. Shi Y, Vattem KM, Sood R, et al. Identification and characterization of pancreatic eukaryotic initiation factor 2áalpha-subunit kinase, PEK, involved in translational control. Mol Cell Biol. 1998;18:7499–7509
  31. Sidrauski C, Chapman R, Walter P. The unfolded protein response: an intracellular signalling pathway with many surprising features. Trends Cell Biol. 1998;8:245–249
  32. Tsai B, Ye Y, Rapoport TA. Retro-translocation of proteins from the endoplasmic reticulum into the cytosol. Nat Rev Mol Cell Biol. 2002;4:246–255
  33. Vela J, Gutierrez A, Vitorica J, Ruano D. Rat hippocampal GABAergic molecular markers are differentially affected by ageing. J Neurochem. 2003;85:368–377
  34. Vela J, Vitorica J, Ruano D. Rapid PCR-mediated synthesis of competitor molecules for accurate quantification of beta2 GABA(A) receptor subunit mRNA. Brain Res Protoc. 2001;8:184–190
  35. Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell. 2001;107:881–891
  36. Zinszner H, Kuroda M, Wang X, et al. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev. 1998;12:982–995

PII: S0197-4580(05)00146-6

doi: 10.1016/j.neurobiolaging.2005.05.010

Neurobiology of Aging
Volume 27, Issue 7 , Pages 973-982 , July 2006

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