Neurobiology of Aging
Volume 26, Issue 7 , Pages 1029-1033 , July 2005

Estradiol or estradiol/progesterone treatment in older women: no strong effects on cognition

  • Oliver T. Wolf

      Affiliations

    • Institute of Experimental Psychology, University of Duesseldorf, Universitaetsstrasse 1, D-40225 Duesseldorf, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 211 81 11779; fax: +49 211 81 12019.
    • ,
  • Antje B. Heinrich

      Affiliations

    • Institute of Experimental Psychology, University of Duesseldorf, Universitaetsstrasse 1, D-40225 Duesseldorf, Germany
    • ,
  • Bettina Hanstein

      Affiliations

    • Department of Obstetrics and Gynecology, University Hospital Duesseldorf, Germany
    • ,
  • Clemens Kirschbaum

      Affiliations

    • Department of Psychology, Dresden University of Technology, Dresden, Germany

Received 9 June 2004 ,Revised 20 September 2004 ,Accepted 28 September 2004.

References 

  1. Adams MM, Morrison JH. Estrogen and the aging hippocampal synapse. Cereb Cortex. 2003;13:1271–1275
  2. Brickenkamp R. Test d2: Aufmerksamkeits-Belastungs-Test, Handanweisungen. Göttingen: Hogrefe; 1994;
  3. Cohen J. Statistical power analysis for the social sciences. New York: Academic Press; 1977;
  4. Erdfelder E, Faul F, Buchner A. G*Power: a general power analysis program. Behav Res Methods Instrum Comput. 1996;28:1–11
  5. Espeland MA, Rapp SR, Shumaker SA, Brunner R, Manson JE, Sherwin BB, et al. Conjugated equine estrogens and global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study. J Am Med Assoc. 2004;291:2959–2968
  6. Gibbs RB. Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats. Neurobiol Aging. 2000;21:107–116
  7. Hogervorst E, Williams J, Budge M, Riedel W, Jolles J. The nature of the effect of female gonadal hormone replacement therapy on cognitive function in post-menopausal women: a meta-analysis. Neuroscience. 2000;101:485–512
  8. Horn W. Leistungspruefsystem (LPS). Göettingen, Germany: Hogrefe; 1983;
  9. LeBlanc ES, Janowsky J, Chan BKS, Nelson HD. Hormone replacement therapy and cognition: systematic review and meta-analysis. J Am Med Assoc. 2001;285:1489–1499
  10. McEwen BS, Alves SE. Estrogen actions in the central nervous system. Endocr Rev. 1999;20:279–307
  11. Phillips SM, Sherwin BB. Effects of estrogen on memory function in surgically menopausal women. Psychoneuroendocrinology. 1992;17:485–495
  12. Rapp PR, Morrison JH, Roberts JA. Cyclic estrogen replacement improves cognitive function in aged ovariectomized rhesus monkeys. J Neurosci. 2003;23:5708–5714
  13. Rapp SR, Espeland MA, Shumaker SA, Henderson VW, Brunner RL, Manson JE, et al. Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. J Am Med Assoc. 2003;289:2663–2672
  14. Resnick SM, Henderson VW. Hormone therapy and risk of Alzheimer disease: a critical time. J Am Med Assoc. 2002;288:2170–2172
  15. Sherwin BB. Estrogen and cognitive functioning in women. Endocr Rev. 2003;24:133–151
  16. Shumaker SA, Legault C, Kuller L, Rapp SR, Thal L, Lane DS, et al. Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study. J Am Med Assoc. 2004;291:2947–2958
  17. Shumaker SA, Legault C, Thal L, Wallace RB, Ockene JK, Hendrix SL, et al. Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial. J Am Med Assoc. 2003;289:2651–2662
  18. Toran-Allerand CD. Estrogen as a treatment for Alzheimer disease. J Am Med Assoc. 2000;284:307–308
  19. Wolf OT, Kudielka BM, Hellhammer DH, Torber S, McEwen BS, Kirschbaum C. Two weeks of transdermal estradiol treatment in postmenopausal elderly women and its effect on memory and mood: verbal memory changes are associated with the treatment induced estradiol levels. Psychoneuroendocrinology. 1999;24:727–741

PII: S0197-4580(04)00316-1

doi: 10.1016/j.neurobiolaging.2004.09.012

Neurobiology of Aging
Volume 26, Issue 7 , Pages 1029-1033 , July 2005

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