Neurobiology of Aging
Volume 26, Issue 7 , Pages 1001-1004 , July 2005

Interaction of herpesviridae, APOE gene, and education in cognitive impairment

  • Timo E Strandberg

      Affiliations

    • Department of Medicine, Geriatric Clinic, University of Helsinki, P.O. Box 340, FIN-00029 HUS, Finland
    • Corresponding Author InformationCorresponding author. Tel.: +358 40 5969285; fax: +358 9 471 74013.
    • ,
  • Kaisu Pitkala

      Affiliations

    • Department of Medicine, Geriatric Clinic, University of Helsinki, P.O. Box 340, FIN-00029 HUS, Finland
    • ,
  • Johanna Eerola

      Affiliations

    • Department of Neurology, Helsinki University Central Hospital, Neuroscience Programme, University of Helsinki, Biomedicum-Helsinki, Haartmaninkatu 8, P.O. Box 700, Helsinki, Finland
    • ,
  • Reijo Tilvis

      Affiliations

    • Department of Medicine, Geriatric Clinic, University of Helsinki, P.O. Box 340, FIN-00029 HUS, Finland
    • ,
  • Pentti J. Tienari

      Affiliations

    • Department of Neurology, Helsinki University Central Hospital, Neuroscience Programme, University of Helsinki, Biomedicum-Helsinki, Haartmaninkatu 8, P.O. Box 700, Helsinki, Finland

Received 25 May 2004 ,Revised 19 August 2004 ,Accepted 15 September 2004.

References 

  1. Burgos JS, Ramirez C, Sastre I, Bullido MJ, Valdivieso F. ApoE4 is more efficient than E3 in brain access by herpes simplex virus type 1. Neuroreport. 2003;14:1825–1827
  2. Dickerson FB, Boronow JJ, Stallings C, Origoni AE, Ruslanova I, Yolken RH. Association of serum antibodies to herpes simplex virus 1 with cognitive deficits in individuals with schizophrenia. Arch Gen Psychiatr. 2003;60:466–472
  3. Dobson CB, Wozniak MA, Itzhaki RF. Do infectious agents play a role in dementia?. Trends Microbiol. 2003;1:312–317
  4. Hemling N, Roytta M, Rinne J, Polanen P, Broberg E, Tapio V, et al. Herpesviruses in brains of Alzheimer's and Parkinson's diseases. Ann Neurol. 2003;54:267–271
  5. Holmes C, El-Okl M, Williams AL, Cunningham C, Wilcockson D, Perry VH. Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer disease. J Neurol Neurosurg Psychiatr. 2003;74:788–789
  6. Itzhaki RF, Lin WR, Shang D, Wilcock GK, Faragher B, Jamieson GA. Herpes simplex virus type 1 in brain and risk of Alzheimer's disease. Lancet. 1997;349:241–244
  7. Myllykangas L, Polvikoski T, Reunanen K, Wavrant-De Vrieze F, Ellis C, Hernandez D, et al. ApoE ɛ3 haplotype modulates Alzheimer beta-amyloid deposition in the brain. Am J Med Genet. 2002;114:288–291
  8. Satpute-Krishnan P, DeGiorgis JA, Bearer EL. Fast anterograde transport of herpes simplex virus: role for the amyloid precursor protein of Alzheimer's disease. Aging Cell. 2003;2:305–318
  9. Strandberg TE, Pitkälä K, Bergling S, Nieminen MS, Tilvis RS. Multifactorial cardiovascular disease prevention in patients aged 75 years and older: a randomized controlled trial. Am Heart J. 2001;142:945–951
  10. Strandberg TE, Pitkälä K, Linnavuori K, Tilvis RS. Impact of viral and bacterial burden on cognitive impairment in elderly persons with cardiovascular diseases. Stroke. 2003;34:2126–2131

PII: S0197-4580(04)00309-4

doi: 10.1016/j.neurobiolaging.2004.09.008

Neurobiology of Aging
Volume 26, Issue 7 , Pages 1001-1004 , July 2005

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