Neurobiology of Aging
Volume 26, Issue 7 , Pages 995-1000 , July 2005

Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models

  • Nilay V. Patel

      Affiliations

    • Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089-0191, USA
    • Present address: Department of Gene Expression and Drug Discovery, City of Hope National Cancer Center, Duarte, CA 91010, USA.
  • ,
  • Marcia N. Gordon

      Affiliations

    • Alzheimer's Research Laboratory, Department of Pharmacology, University of South Florida, Tampa, FL 33162, USA
  • ,
  • Karen E. Connor

      Affiliations

    • Alzheimer's Research Laboratory, Department of Pharmacology, University of South Florida, Tampa, FL 33162, USA
  • ,
  • Robert A. Good

      Affiliations

    • Alzheimer's Research Laboratory, Department of Pediatrics, University of South Florida, Tampa, FL 33162, USA
  • ,
  • Robert W. Engelman

      Affiliations

    • Alzheimer's Research Laboratory, Department of Pediatrics, University of South Florida, Tampa, FL 33162, USA
  • ,
  • Jerimiah Mason

      Affiliations

    • Alzheimer's Research Laboratory, Department of Pharmacology, University of South Florida, Tampa, FL 33162, USA
  • ,
  • David G. Morgan

      Affiliations

    • Alzheimer's Research Laboratory, Department of Pharmacology, University of South Florida, Tampa, FL 33162, USA
  • ,
  • Todd E. Morgan

      Affiliations

    • Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089-0191, USA
    • T.E.M. and C.E.F. contributed equally to this work.
    • Corresponding Author InformationCorresponding author. Tel.: +1 213 740 4083; fax: +1 213 740 0853.
  • ,
  • Caleb E. Finch

      Affiliations

    • Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089-0191, USA
    • T.E.M. and C.E.F. contributed equally to this work.

Received 13 May 2004 ,Revised 13 August 2004 ,Accepted 20 September 2004.

References 

  1. Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, et al. Inflammation and Alzheimer's disease. Neurobiol Aging. 2000;21:383–421
  2. Bodkin NL, Alexander TM, Ortmeyer HK, Johnson E, Hansen BC. Mortality and morbidity in laboratory-maintained rhesus monkeys and effects of long-term dietary restriction. J Gerontol A Biol Sci Med Sci. 2003;58:212–219
  3. Bornemann KD, Wiederhold KH, Pauli C, Ermini F, Stalder M, Schnell L, et al. Abeta-induced inflammatory processes in microglia cells of APP23 transgenic mice. Am J Pathol. 2001;158:63–73
  4. Bruce-Keller AJ, Umberger G, McFall R, Mattson MP. Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults. Ann Neurol. 1999;45:8–15
  5. Cuenca AG, Cress WD, Good RA, Marikar Y, Engelman RW. Calorie restriction influences cell cycle protein expression and DNA synthesis during liver regeneration. Exp Biol Med (Maywood). 2001;226:1061–1067
  6. DeMattos RB, Cirrito JR, Parsadanian M, May PC, O’Dell MA, Taylor JW, et al. ApoE and clusterin cooperatively suppress Abeta levels and deposition. Evidence that apoE regulates extracellular abeta metabolism in vivo. Neuron. 2004;41:193–202
  7. Dickey CA, Loring JF, Montgomery J, Gordon MN, Eastman PS, Morgan D. Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein+presenilin-1 transgenic mice. J Neurosci. 2003;23:5219–5226
  8. Engelhart MJ, Geerlings MI, Ruitenberg A, Van Swieten JC, Hofman A, Witteman JC, et al. Diet and risk of dementia: does fat matter? The Rotterdam Study. Neurology. 2002;59:1915–1921
  9. Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, et al. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci USA. 2003;100:4162–4167Epub 2003, March 12
  10. Friedland RP, Shi J, Smith MA, Perry G, Sparks DL. Cholesterol feeding enhances cerebral amyloid beta pathology in beagles. Neurobiol Aging. 2004;25:224
  11. Gordon MN, Holcomb LA, Jantzen PT, DiCarlo G, Wilcock D, Boyett KW, et al. Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse. Exp Neurol. 2002;173:183–195
  12. Grant WB. Obesity and Alzheimer disease: roles of diet and genetics. Arch Int Med. 2004;164:109–110author reply 110
  13. Gustafson D, Rothenberg E, Blennow K, Steen B, Skoog I. An 18-year follow-up of overweight and risk of Alzheimer disease. Arch Intern Med. 2003;163:1524–1528
  14. Heilbronn LK, Ravussin E. Calorie restriction and aging: review of the literature and implications for studies in humans. Am J Clin Nutr. 2003;78:361–369
  15. Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med. 1998;4:97–100
  16. Laitinen MH, Helkala E-L, Uusitalo U, Nissinen A, Tuomilehto J, Soininen H, et al. Midlife dietary fats and the risk of late-life dementia: a population-based study. Neurobiol Aging. 2004;25:399
  17. Lee CK, Weindruch R, Prolla TA. Gene-expression profile of the ageing brain in mice. Nat Genet. 2000;25:294–297
  18. Luchsinger JA, Tang MX, Shea S, Mayeux R. Caloric intake and the risk of Alzheimer disease. Arch Neurol. 2002;59:1258–1263
  19. Mattson MP. Gene-diet interactions in brain aging and neurodegenerative disorders. Ann Intern Med. 2003;139:441–444
  20. Morgan TE, Xie Z, Goldsmith S, Yoshida T, Lanzrein AS, Stone D, et al. The mosaic of brain glial hyperactivity during normal ageing and its attenuation by food restriction. Neuroscience. 1999;89:687–699
  21. Mrak RE, Griffinbc WS. The role of activated astrocytes and of the neurotrophic cytokine S100B in the pathogenesis of Alzheimer's disease. Neurobiol Aging. 2001;22:915–922
  22. Mucke L, Masliah E, Yu GQ, Mallory M, Rockenstein EM, Tatsuno G, et al. High-level neuronal expression of abeta 1–42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci. 2000;20:4050–4058
  23. Nichols NR, Day JR, Laping NJ, Johnson SA, Finch CE. GFAP mRNA increases with age in rat and human brain. Neurobiol Aging. 1993;14:421–429
  24. Olgun A, Akman S, Serdar MA, Kutluay T. Oxidative phosphorylation enzyme complexes in caloric restriction. Exp Gerontol. 2002;37:639–645
  25. Patel NV, Finch CE. The glucocorticoid paradox of caloric restriction in slowing brain aging. Neurobiol Aging. 2002;23:707–717
  26. Petot GJ, Fritsch T, Debanne SM, Traore F, Friedland RP. Obesity during the mid-adult years is a rick factor for AD independent of apoE4 genotype. Neurobiol Aging. 2004;25:305
  27. Puglielli L, Tanzi RE, Kovacs DM. Alzheimer's disease: the cholesterol connection. Nat Neurosci. 2003;6:345–351
  28. Razay G, Vreugdenhil A. AD, abdominal obesity and overweight. Neurobiol Aging. 2004;25:393
  29. Refolo LM, Malester B, LaFrancois J, Bryant-Thomas T, Wang R, Tint GS, et al. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol Dis. 2000;7:321–331
  30. Rogers J, Strohmeyer R, Kovelowski CJ, Li R. Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide. Glia. 2002;40:260–269
  31. Sheng JG, Mrak RE, Griffin WS. Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain. Acta Neuropathol (Berl). 1998;95:229–234
  32. Shie FS, Jin LW, Cook DG, Leverenz JB, LeBoeuf RC. Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic mice. NeuroReport. 2002;13:455–459
  33. Sparks DL, Kuo YM, Roher A, Martin T, Lukas RJ. Alterations of Alzheimer's disease in the cholesterol-fed rabbit, including vascular inflammation. Preliminary observations. Ann N Y Acad Sci. 2000;903:335–344
  34. Tokuda T, Oide T, Tamaoka A, Ishii K, Matsuno S, Ikeda S. Prednisolone (30–60mg/day) for diseases other than AD decreases amyloid beta-peptides in CSF. Neurology. 2002;58:1415–1418
  35. Watson GS, Peskind ER, Asthana S, Purganan K, Wait C, Chapman D, et al. Insulin increases CSF Abeta42 levels in normal older adults. Neurology. 2003;60:1899–1903
  36. Wyss-Coray T, Loike JD, Brionne TC, Lu E, Anankov R, Yan F, et al. Adult mouse astrocytes degrade amyloid-beta in vitro and in situ. Nat Med. 2003;9:453–457

PII: S0197-4580(04)00307-0

doi: 10.1016/j.neurobiolaging.2004.09.014

Neurobiology of Aging
Volume 26, Issue 7 , Pages 995-1000 , July 2005