Neurobiology of Aging
Volume 26, Issue 7 , Pages 1011-1014 , July 2005

Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease

  • Nobuto Shibata

      Affiliations

    • Department of Psychiatry, Juntendo University School of Medicine. 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan.
    • Corresponding Author InformationCorresponding author. Tel.: +81 3 5802 1071; fax: +81 3 5802 1071.
  • ,
  • Tohru Ohnuma

      Affiliations

    • Department of Psychiatry, Juntendo University School of Medicine. 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan.
  • ,
  • Shinji Higashi

      Affiliations

    • Department of Psychiatry, Juntendo University School of Medicine. 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan.
  • ,
  • Chie Usui

      Affiliations

    • Department of Psychiatry, Juntendo University School of Medicine. 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan.
  • ,
  • Taku Ohkubo

      Affiliations

    • Department of Psychiatry, Juntendo University School of Medicine. 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan.
  • ,
  • Akiyoshi Kitajima

      Affiliations

    • Department of Psychiatry, Juntendo University School of Medicine. 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan.
  • ,
  • Akira Ueki

      Affiliations

    • Department of Neurology, Omiya Medical Center, Jichi Medical School. 1-847 Amanuma-chou, Omiya-shi, Saitama, 330-0834 Japan.
  • ,
  • Masatsugu Nagao

      Affiliations

    • Department of Psychiatry, Nagao Hospital. 1-14-15 Aga kita, kure-shi Hiroshima, 737-0001 Japan.
  • ,
  • Heii Arai

      Affiliations

    • Department of Psychiatry, Juntendo University School of Medicine. 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan.

Received 19 April 2004 ,Revised 11 August 2004 ,Accepted 7 September 2004.

References 

  1. Asahina M, Yoshiyama Y, Hattori T. Expression of matrix metalloproteinase-9 and urinary-type plasminogen activator in Alzheimer's disease brain. Clin Neuropathol. 2001;20(2):60–63
  2. Backstrom JR, Lim GP, Cullen MJ, Tokes ZA. Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1–40). J Neurosci. 1996;16(24):7910–7919
  3. Beyzade S, Zhang S, Wong YK, Day IN, Eriksson P, Ye S. Influences of matrix metalloproteinase-3 gene variation on extent of coronary atherosclerosis and risk of myocardial infarction. J Am Coll Cardiol. 2003;41(12):2130–2137
  4. Ghilardi G, Biondi ML, DeMonti M, Turri O, Guagnellini E, Scorza R. Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with carotid artery stenosis. Stroke. 2002;33(10):2408–2412
  5. Helbecque N, Hermant X, Cottel D, Amouyel P. The role of matrix metalloproteinase-9 in dementia. Neurosci Lett. 2003;350(3):181–183
  6. Holla LI, Vasku A, Stejskalova A, Znojil V. Functional polymorphism in the gelatinase B gene and asthma. Allergy. 2000;55(9):900–901
  7. Liu PY, Chen JH, Li YH, Wu HL, Shi GY. Synergistic effect of stromelysin-1 (matrix metallo-proteinase-3) promoter 5A/6A polymorphism with smoking on the onset of young acute myocardial infarction. Thromb Haemost. 2003;90(1):132–139
  8. Lorenzl S, Albers DS, Relkin N, Ngyuen T, Hilgenberg SL, Chirichigno J, et al. Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer's disease. Neurochem Int. 2003;43(3):191–196
  9. Maeda S, Haneda M, Guo B, Koya D, Hayashi K, Sugimoto T, et al. Dinucleotide repeat polymorphism of matrix metalloproteinase-9 gene is associated with diabetic nephropathy. Kidney Int. 2001;60(4):1428–1434
  10. Minematsu N, Nakamura H, Tateno H, Nakajima T, Yamaguchi K. Genetic polymorphism in matrix metalloproteinase-9 and pulmonary emphysema. Biochem Biophys Res Commun. 2001;289(1):116–119
  11. Peters DG, Kassam A, St Jean PL, Yonas H, Ferrell RE. Functional polymorphism in the matrix metalloproteinase-9 promoter as a potential risk factor for intracranial aneurysm. Stroke. 1999;30(12):2612–2616
  12. Pollanen PJ, Karhunen PJ, Mikkelsson J, Laippala P, Perola M, Penttila A, et al. Coronary artery complicated lesion area is related to functional polymorphism of matrix metalloproteinase 9 gene: an autopsy study. Arterioscler Thromb Vasc Biol. 2001;21(9):1446–1450
  13. Szyllo K, Smolarz B, Romanowicz-Makowska H, Niewiadomski M, Kozlowska E, Kulig A. The promoter polymorphism of the matrix metalloproteinase 3 (MMP-3) gene in women with ovarian cancer. J Exp Clin Cancer Res. 2002;21(3):357–361
  14. Terashima M, Akita H, Kanazawa K, Inoue N, Yamada S, Ito K, et al. Stromelysin promoter 5A/6A polymorphism is associated with acute myocardial infarction. Circulation. 1999;99(21):2717–2719
  15. Wang J, Warzecha D, Wilcken D, Wang XL. Polymorphism in the gelatinase B gene and the severity of coronary arterial stenosis. Clin Sci (Lond). 2001;101(1):87–92
  16. Ye S. Polymorphism in matrix metalloproteinase gene promoters: implication in regulation of gene expression and susceptibility of various diseases. Matrix Biol. 2000;19(7):623–629
  17. Yong VW, Krekoski CA, Forsyth PA, Bell R, Edwards DR. Matrix metalloproteinases and diseases of the CNS. Trends Neurosci. 1998;21(2):75–80
  18. Yoshiyama Y, Asahina M, Hattori T. Selective distribution of matrix metalloproteinase-3 (MMP-3) in Alzheimer's disease brain. Acta Neuropathol (Berl). 2000;99(2):91–95
  19. Yoshiyama Y, Sato H, Seiki M, Shinagawa A, Takahashi M, Yamada T. Expression of the membrane-type 3 matrix metalloproteinase (MT3-MMP) in human brain tissues. Acta Neuropathol (Berl). 1998;96(4):347–350
  20. Zhang B, Ye S, Herrmann SM, Eriksson P, de Maat M, Evans A, et al. Functional polymorphism in the regulatory region of gelatinase B gene in relation to severity of coronary atherosclerosis. Circulation. 1999;99(14):1788–1794

PII: S0197-4580(04)00303-3

doi: 10.1016/j.neurobiolaging.2004.09.004

Neurobiology of Aging
Volume 26, Issue 7 , Pages 1011-1014 , July 2005