Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease

Shibata, Nobuto; Ohnuma, Tohru; Higashi, Shinji; Usui, Chie; Ohkubo, Taku; Kitajima, Akiyoshi; Ueki, Akira; Nagao, Masatsugu; Arai, Heii

doi:10.1016/j.neurobiolaging.2004.09.004

« Previous Next »Neurobiology of Aging
Volume 26, Issue 7 , Pages 1011-1014, July 2005

Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease

Nobuto Shibata
- Department of Psychiatry, Juntendo University School of Medicine. 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan.
- Corresponding author. Tel.: +81 3 5802 1071; fax: +81 3 5802 1071.
Tohru Ohnuma
- Department of Psychiatry, Juntendo University School of Medicine. 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan.
Shinji Higashi
- Department of Psychiatry, Juntendo University School of Medicine. 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan.
Chie Usui
- Department of Psychiatry, Juntendo University School of Medicine. 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan.
Taku Ohkubo
- Department of Psychiatry, Juntendo University School of Medicine. 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan.
Akiyoshi Kitajima
- Department of Psychiatry, Juntendo University School of Medicine. 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan.
Akira Ueki
- Department of Neurology, Omiya Medical Center, Jichi Medical School. 1-847 Amanuma-chou, Omiya-shi, Saitama, 330-0834 Japan.
Masatsugu Nagao
- Department of Psychiatry, Nagao Hospital. 1-14-15 Aga kita, kure-shi Hiroshima, 737-0001 Japan.
Heii Arai
- Department of Psychiatry, Juntendo University School of Medicine. 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 Japan.

Received 19 April 2004; received in revised form 11 August 2004; accepted 7 September 2004.

Abstract

Recent studies suggested that matrix metalloproteinases (MMPs) might play an important role in the pathophysiology of Alzheimer's disease (AD). MMP-9 and MMP–3 are reported to degrade amyloid β and have several functional polymorphisms associated with other common diseases. Four common polymorphisms in each of MMP-9 and MMP–3 were examined in AD cases and normal control individuals. Common polymorphisms of MMP-9, rs3918248, rs2664538, rs2250889 and rs2274756 showed no association with risk for AD. We observed strong linkage disequilibrium (LD) between rs2664538 and rs2250889 in our Japanese samples. The polymorphisms of MMP-3; 5A/6A insertion polymorphism in the promoter, rs3025079, rs520540 and rs679620 also did not influence risk for AD. LD of the 5A/6A polymorphism with rs679620 was relatively strong. These results suggest that the common polymorphisms of MMP-9 and MMP–3 investigated here are not associated with AD.

Keywords: Alzheimer's disease, Matrix metalloproteinases, Genetic polymorphism