Neurobiology of Aging
Volume 25, Issue 3 , Pages 341-348 , March 2004

BDNF is necessary for maintenance of noradrenergic innervations in the aged rat brain

Received 2 January 2003 ,Revised 19 March 2003 ,Accepted 2 April 2003.

References 

  1. Allendoerfer KL, Cabelli RJ, Escandon E, Kaplan DR, Nikolics K, Shatz CJ. Regulation of neurotrophin receptors during the maturation of the mammalian visual system. J. Neurosci. 1994;14:1795–1811
  2. Amaral DG, Sinnamon HE. The locus coeruleus: neurobiology of a central noradrenergic nucleus. Prog. Neurobiol. 1977;9:147–196
  3. Armanini MP, McMahon SB, Sutherland J, Shelton DL, Phillips HS. Truncated and catalytic isoforms of TrkB are co-expressed in neurons of rat and mouse CNS. Eur. J. Neurosci. 1995;7:1403–1409
  4. Aston-Jones G, Bloom FE. Nonrepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli. J. Neurosci. 1981;1:887–900
  5. Bamber NI, Li H, Lu X, Oudega M, Aebischer P, Xu XM. Neurotrophins BDNF and NT-3 promote axonal re-entry into the distal host spinal cord through Schwann cell-seeded mini-channels. Eur. J. Neurosci. 2001;13:257–268
  6. Barbacid M. The Trk family of neurotrophin receptors. J. Neurobiol. 1994;25:1386–1403
  7. Barde Y-A, Edgar D, Thoenen H. Purification of a new neurotrophic factor from mammalian brain. EMBO J. 1982;1:549–553
  8. Conner JM, Lauterborn JC, Yan Q, Gall CM, Varon S. Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport. J. Neurosci. 1997;17:2295–2313
  9. DiStefano PS, Friedman B, Radziejewski C, Alexander C, Boland P, Schick CM, et al.  The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons. Neuron. 1992;8:983–993
  10. Escandon E, Soppet D, Rosenthal A, Mendoza-Ramirez JL, Szonyi E, Burton LE, et al.  Regulation of neurotrophin receptor expression during embryonic and postnatal development. J. Neurosci. 1994;14:2054–2068
  11. Fawcett JP, Bamji SX, Causing CG, Aloyz R, Ase AR, Reader TA, et al.  Functional evidence that BDNF is an anterograde neuronal trophic factor in the CNS. J. Neurosci. 1998;18:2808–2821
  12. Foote SL, Aston-Jones G, Bloom FE. Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal. Proc. Natl. Acad. Sci. U.S.A. 1980;77:3033–3037
  13. Freedman WJ, Ibanez CF, Hallbook F, Person H, Cain LD, Dreyfus CF, et al.  Differential actions of neuritrophins in the locus coeruleus and basal forbrain. Exp. Neurol. 1993;119:72–78
  14. Frisen J, Verge VM, Fried K, Risling M, Persson H, Trotter J, et al.  Characterization of glial TrkB receptors: differential response to injury in the central and peripheral nervous systems. Proc. Natl. Acad. Sci. U.S.A. 1993;90:4971–4975
  15. Glass DJ, Nye SH, Hantzopoulos P, Macchi MJ, Squinto SP, Goldfarb M, et al.  TrkB mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor. Cell. 1991;66:405–413
  16. Goldman G, Coleman PD. Neuron numbers in locus coeruleus do not change with age in Fisher 344 rat. Neurobiol. Aging. 1981;2:33–36
  17. Inoue A, Sanes JR. Lamina-specific connectivity in the brain: regulation by N-cadherin, neurotrophins, and glycoconjugates. Science. 1997;276:1428–1431
  18. Ishida Y, Shirokawa T, Komatsu Y, Isobe K. Changes in cortical noradrenergic axon terminals of locus coeruleus neurons in aged F344 rats. Neurosci. Lett. 2001;307:197–199
  19. Ishida Y, Shirokawa T, Miyaishi O, Komatsu Y, Isobe K. Age-dependent changes in projections from locus coeruleus to hippocampus dentate gyrus and frontal cortex. Eur. J. Neurosci. 2000;12:1263–1270
  20. Ishida Y, Shirokawa T, Miyaishi O, Komatsu Y, Isobe K. Age-dependent changes in noradrenergic innervations of the frontal cortex in F344 rats. Neurobiol. Aging. 2001;22:283–286
  21. Lohof AM, Ip NY, Poo MM. Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF. Nature. 1993;363:350–353
  22. Mamounas LA, Altar CA, Blue ME, Kaplan DR, Tessarollo L, Lyons WE. BDNF promotes the regenerative sprouting but not survival of injured serotonergic axons in the adult rat brain. J. Neurosci. 2000;20:771–782
  23. Moore RY, Bloom FE. Central catecholamine neuron system: anatomy and physiology of norepinephrine and epinephrine systems. Annu. Rev. Neurosci. 1979;2:113–168
  24. Morrison JH, Molliver ME, Grzanna R. Noradrenergic innervation of cerebral cortex: widespread effect of local cortical lesions. Science. 1979;205:313–316
  25. Numan S, Lane-Ladd SB, Zhang L, Lundgren KH, Russell DS, Seroogy KB, et al.  Differential regulation of neurotrophin and trk receptor mRNAs in catecholaminergic nuclei during chronic opiate treatment and withdrawal. J. Neurosci. 1998;18:10700–10708
  26. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 2nd ed. San Diego: Academic Press; 1986.
  27. Plaznik A, Danysz W, Kostowski W, Bidzinski A, Hauptmann M. Interaction between noradrenergic and serotonergic brain systems as evidenced by behavioral and biochemical effects of microinjections of adrenergic agonists and antagonists into the median raphe nucleus. Pharmacol. Biochem. Behav. 1983;19:27–32
  28. Robbins TW. Cortical noradrenaline, attention and arousal. Psychol. Med. 1984;14:13–21
  29. Robbins TW, Everitt BJ. Functional studies of the central catecholamines. Int. Rev. Neurobiol. 1982;23:303–365
  30. Segal M, Bloom FE. The action of norepinephrine in the rat hippocampus. IV. The effects of locus coeruleus stimulation on evoked hippocampal unit activity. Brain Res. 1976;107:513–525
  31. Shirokawa T, Ishida Y, Isobe KI. Age-dependent changes in axonal branching of single locus coeruleus neurons projecting to two different terminal fields. J. Neurophysiol. 2000;84:1120–1122
  32. Sklair-Tarvon L, Nestler BJ. Opposing effects of morphine and the neurotrophins, NT-3, NT-4 and BDNF, on locus coeruleus neurons in vitro. Brain Res. 1995;702:117–125
  33. Sobreviela T, Pagcatipunan M, Kroin JS, Mufson EJ. Retrograde transport of brain-derived neurotrophic factor (BDNF) following infusion in neo- and limbic cortex in rat: relationship to BDNF mRNA expressing neurons. J. Comp. Neurol. 1996;375:417–444
  34. Stock G, Rupprecht U, Stumpf H, Schlor KH. Cardiovascular changes during arousal elicited by stimulation of amygdala, hypothalamus and locus coeruleus. J. Auton. Nerv. Syst. 1981;3:503–510
  35. Stockmeier CA, Martino AM, Kellar KJ. A strong influence of serotonin axons on beta-adrenergic receptors in rat brain. Science. 1985;230:323–325
  36. Swanson LW, Hartman BK. The central noradrenergic system. An immunofluorescence study of the location of the cell bodies and their efferent connections in the rat utilizing dopamine-β-hydroxylase as a marker. J. Comp. Neurol. 1975;163:467–507
  37. Thoenen H. The changing scene of neurotrophic factors. Trends Neurosci. 1991;14:165–170
  38. van Luijtelaar MG, Tonnaer JA, Steinbusch HW. Aging of the serotonergic system in the rat forebrain: an immunocytochemical and neurochemical study. Neurobiol. Aging. 1992;13:201–215
  39. Ventimiglia R, Mather PE, Jones BE, Lindsay RM. The neurotrophins BDNF NT-3 and NT-4/5 promote survival and morphological and biochemical differentiation of striatal neurons in vitro. Eur. J. Neurosci. 1998;7:213–222
  40. Weidenfeld J, Feldman S, Itzik A, Van de Kar LD, Newman ME. Evidence for a mutual interaction between noradrenergic and serotonergic agonists in stimulation of ACTH and corticosterone secretion in the rat. Brain Res. 2002;941:113–117

PII: S0197-4580(03)00093-9

doi: 10.1016/S0197-4580(03)00093-9

Neurobiology of Aging
Volume 25, Issue 3 , Pages 341-348 , March 2004

Article Tools

* Image Usage & Resolution