Neurobiology of Aging
Volume 24, Issue 1 , Pages 179-186 , January 2003

β-Amyloid(1–40)-induced apoptosis of cultured cortical neurones involves calpain-mediated cleavage of poly-ADP-ribose polymerase

Received 14 November 2001 ,Revised 16 April 2002 ,Accepted 23 April 2002.

References 

  1. Adamec E, Vonsattel JP, Nixon RA. DNA strand breaks in Alzheimer’s disease. Brain Res. 1999;849(1/2):67–77
  2. Ariyoshi H, Okahara K, Sakon M, Kambayashi J, Kawashima S, Kawasaki T, et al.  Possible involvement of calpain in vascular smooth muscle proliferation. Arterioscler. Throm. Vasc. Biol. 1998;18(3):493–498
  3. Bi X, Chen J, Baudry M. Developmental changes in calpain activity, GluR1 receptors and the effect of kainic acid treatment in rat brain. Neuroscience. 1997;81(4):1123–1135
  4. Bosman G, Renkawek K, Van Workum FPA, Bartholomeus IGP, De Grip WJ. Involvement of anion exchange proteins in cell death in Alzheimer’s disease. Gerontology. 1997;43:67–78
  5. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of proteins utilising the principle of protein dye binding. Anal. Biochem. 1976;72:248–254
  6. Cheng AG, Huang T, Stracher A, Kim A, Liu W, Malgrange B, et al.  Calpain inhibitors protect auditory sensory cells from hypoxia and neurotrophin-withdrawal-induced apoptosis. Brain Res. 1999;850:234–243
  7. Desjardins P, Ledoux S. Expression of ced-3 and ced-9 homologs in Alzheimer’s disease cerebral cortex. Neurosci. Lett. 1998;244(2):69–72
  8. P R, Johnson GV. Oxidative stress inhibits calpain activity in situ. J. Biol. Chem. 1998;273:13331–13338
  9. Harada J, Sugimotot M. Activation of caspase-3 in β-amyloid-induced apoptosis of cultured rat cortical neurones. Brain Res. 1999;842:311–323
  10. Jordan J, Galindo MF, Miller RJ. Role of calpain and interleukin-1β converting enzyme-like proteases in the β-amyloid-induced death of rat hippocampal neurones in culture. J. Neurochem. 1997;68:1612–1621
  11. Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Multhaup G, et al.  The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor. Nature. 1987;325:733–736
  12. Lazebnik YA. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature. 1994;371:346–347
  13. Li YP, Bushnell AF, Lee CM, Perlmutter LS, Wong SK. β-Amyloid induces apoptosis in human-derived neurotypic SH-SY5Y cells. Brain Res. 1996;738(2):196–204
  14. Lu X, Rong Y, Baudry M. Calpain-mediated degradation of PSD-95 in developing and adult rat brain. Neurosci. Lett. 2000;286(2):149–153
  15. MacManus A, Ramsden M, Murray M, Pearson HA, Campbell V. Enhancement of 45Ca 2+ influx and voltage-dependent Ca2+ channel activity by β-amyloid(1–40) in rat cortical synaptosomes and cultured cortical neurones: modulation by the proinflammatory cytokine interleukin-1β. J. Biol. Chem. 2000;275(5):4713–4718
  16. Mattson M. Mechanism of neuronal degeneration and preventative approaches: quickening the pace of AD research. Neurobiol. Aging. 1994;15(2):S121–S125
  17. McConkey DJ, Orrenius S. The role of calcium in the regulation of apoptosis. Biochem. Biophys. Res. Commun. 1997;239:357–366
  18. McGinnis KM, Gnegy ME, Park YH, Mukrjee N, Wang KK. Procaspase-3 and poly(ADP)ribose polymerase (PARP) are calpain substrates. Biochem. Biophys. Res. Commun. 1999;263:94–99
  19. Mehdi M. Cell-penetrating inhibitors of calpain. Trends Biochem. Sci. 1991;16:150–153
  20. Mellgren RL, Shaw E, Mericle MT. Inhibition of growth of human TE2 and C-33A cells by the cell-permeable calpain inhibitor benzyloxycarbonyl-Leu-Leu-Tyr diazomethyl ketone. Exp. Cell Res. 1994;215(1):164–171
  21. Miller DL, Papayannopoulos IA, Styles J, Bobin SA, Lin YY, Bieman K, et al.  Peptide composition of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer’s disease. Arch. Biochem. Biophys. 1993;301:41–52
  22. Miranda S, Opazo C, Larrondo LF, Munoz FJ, Ruiz F, Leighton F, et al.  The role of oxidative stress in the toxicity induced by β-amyloid peptide in Alzheimer’s disease. Prog. Neurobiol. 2000;62(6):633–648
  23. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yanker BA, et al.  Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β. Nature. 2000;403:98–103
  24. Nath R, Raser KJ, Stafford D, Hajimohammadreza I, Posner A, Allen H, et al.  Non-erythroid alpha-spectrin breakdown by calpain and interlukin-1β converting enzyme-like protease(s) in apoptotic cells, contributory role of both protease families in neuronal apoptosis. Biochem. J. 1996;319:683–690
  25. Pieper AA, Verma A, Zhang J, Snyder SH. Poly (ADP-ribose) polymerase, nitric oxide and cell death. Trends in Pharmacol. Sci. 1999;20:171–181
  26. Ruiz-Vela A, Gonzalez de Buitrago G, Martinez C. Implication of calpain in caspase activation during B cell clonal deletion. EMBO J. 1999;18(18):4988–4998
  27. Saez-Valero J, Angeretti N, Forloni G. Caspase-3 activation by β-amyloid and prion protein peptides is independent from their neurotoxic effect. Neurosci. Lett. 2000;293:207–210
  28. Selznick LA, Holtzman DM, Han BH, Gokden M, Srinivasan AN, Johnson EM, et al.  In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease. J. Neuropathol. Exp. Neurol. 1999;58:1020–1026
  29. Selznick LA, Zheng TS, Flavell RA, Rakic P, Roth KA. Aβ-induced neuronal death is bax-dependent but caspase-independent. J. Neuropathol. Exp. Neurol. 2000;59:271–279
  30. Sheilds DC, Schaecher KE, Hogan EL, Banik NL. Calpain activity and expression increased in activated glial and inflammatory cells in penumbra of spinal cord injury lesion. J. Neurosci. Res. 2000;62:146–150
  31. Shimohama S, Suenga T, Araki W, Yamaoaka Y, Shimizu K, Kimurs J. Presence of calpain II immunoreactivity in senile plaques in Alzheimer’s disease. Brain Res. 1991;558(1):105–108
  32. Sindram D, Kohl V, Madden JF, Clavien PA. Calpain inhibition prevents sinusoidal endothelial cell apoptosis in the cold ischemic rat liver. Transplantation. 1999;68:136–140
  33. Stadelmann C, Deckworth TL, Srinivasan A, Bancher C, Bruck W, Jellinger K, et al.  Activation of caspase-3 in single neurones and autophagic granules of granulovacular degeneration in Alzheimer’s disease. Evidence for apoptotic cell death. Am. J. Pathol. 1999;155:1459–1466
  34. Suo Z, Fang C, Crawford F, Mullan M. Superoxide free radical and intracellular calcium mediate Aβ(1-42)-induced endothelial toxicity. Brain Res. 1997;762(1/2):144–152
  35. Suzuki A. Amyloid β-protein induces necrotic cell death mediated by ICE cascade in PC12 cells. Exp. Cell Res. 1997;234:507–511
  36. Troy CM, Rabacchi SA, Friedman WJ, Frappier TF, Brown K, Shelanski ML. Caspase-2 mediates neuronal cell death induced by β-amyloid. J. Neurosci. 2000;20:1386–1392
  37. Wang KKW. Calpain and caspase: can you tell the difference?. Trends Neurosci. 2000;23:20–26
  38. Lazebnik YA. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature. 1994;371:346–347

PII: S0197-4580(02)00060-X

Neurobiology of Aging
Volume 24, Issue 1 , Pages 179-186 , January 2003

Article Tools

* Image Usage & Resolution